» Biography

Dr. Nese Akis Sansa, BChE, MSc, PhD, PDF is an associate professor with tenure in immunology at the Trakya University (TU). She was awarded her Ph.D. in immunology by The University of Istanbul (UI) on 1996. Her dissertation focused on endothelial cell response to diabetic insults. She did her postdoctoral research training at UPenn and its associated centers on DNA-PKcs mutations in leaky scid mice (at FCCC), phase-I trial of an anti-idiotypic cancer vaccine (at The Wistar Institute), and nephritogenic endothelial antigens (at Div. Renal-Electrolyte and Hypertension, Dept. Medicine). Her current interests are atheroprotective genes, and evolution of Ikaros family members. Her area of research expertise includes bioinformatics, molecular biology (PCR, RT-qPCR, cloning), cellular techniques (tissue culture, flow cytometry), immunochemistry, and animal experimentation.

 Dr. Akis graduated with a BChE Degree form UI in 1980, and worked on organic coatings in industrial laboratories till 1985. After moving to Istanbul School of Medicine (I-SOM) at UI she was practised in laboratory medicine of immunology; extended her skills on T cell cytotoxicity and MS diagnosis at The University of Birmingham, and on complementology and its diagnostic applications at The Institue of Enzymology-Budapest; and established a diagnostic laboratory on primary immune deficiencies at I-SOM. She also studied Salmonella OMP antigens in her research for master's thesis (1989). During her predoctoral research training she studied on an anti-idiotypic HBV vaccine at The Institut Pasteur-Paris. In 2003 she was appointed as a faculty member by Halic University Dept. Molecular Biology and Genetics (MBG), where she developed some courses and her reserach program. She taught human physiology and bionformatics for bachelor's students also at the Bogazici University MBG between 2003-2005. After moving to TU-SOM in 2006 she developed some lectures for MD program, and established graduate programs in immunology. She took a learning sabbatical to develop her skills on miRNAs at FAU Erlangen-N in 2012-2013. Her tangiable properties are four anti-bradykinin antibodies (UI DETAM, 1996) and three glomerular cell lines (UPenn CTT TechID: O2748, 2002), and her publications have 783 citations. She holds certifications in Associated Professorship in Immunology, and in High School Teachership in Chemistry, both signed by the National Council of Higher Education in Türkiye. She is a member of UCTEA-CCE, TID, ESM, EVBO, DGfI, and GEBIN. She founded Basic Medical Sciences Commision at Istanbul Medical Chamber in 1991 and Basic Health Scientists Commission at UCTEA-CCE Istanbul Branch in 1992. She headed Education Group of TID between 2012 and 2016. https://unis.trakya.edu.tr/akademisyen/akisn/lang=en

» Academic and Administrative Positions

» Publications

SCI-SSCI or SCI Expanded Articles

  • Pawar RD, L Castrezana-Lopez, R Allam, OP Kulkarni, S Segerer, E Radomska, TN Meyer, CM Schwesinger, N Akis, HJ Gröne, HJ Anders, “ Bacterial Lipopeptide Triggers Massive Albuminuria in Murine Lupus Nephritis By Activating Toll-like Receptor 2 at the Glomerular Filtration Barrier”, Immunology 128(1 Suppl):e206-21 (January 2009)
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  • Ninichuk V, O Gross, S Segerer, R Hoffmann, E Radomska, A Buchstaller, R Huss, N Akis, D Schlondorff, HJ Anders. “Multipotent Mesenchymal Stem Cells Reduce Interstitial Fibrosis But Do Not Delay Progression of Chronic Kidney Disease in Collagen4A3-deficient Mice”, Kidney Int. 70, 121-9 (January 2006)
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  • Feliers D, X Chen, N Akis, GG Choudhury, MP Madaio, BS Kasinath. “VEGF Regulation of Endothelial Nitric Oxide Synthase in Glomerular Endothelial Cells”, Kidney Int. 68, 1648-59 (January 2005)
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  • Akis N, Madaio MP, ‘’Isolation, Culture, and Characterization of Endothelial Cells from Mouse Glomeruli’’, Kidney Int 65(6):2223-7 (January 2004)
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  • Birebent, B., E. Mitchell, N. Akis, W. Li, R. Somasundaram, E. Purev, D. Hoey, M. Mastrangelo, H. Maguire, D. T. Harris, S. Nair, D. Cai, T. Zhang, D. M. Herlyn, “Monoclonal Anti-idiotypic Antibody Mimicking the Gastrointestinal Carcinoma-Associated Epitope CO17-1A Elicits Antigen-Specific Humoral and Cellular Immune Responses in Colorectal Cancer Patients“, Vaccine, 21, 1601-1612 (January 2003)
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  • Akis N, C. Andl, D. Zhou, “A Mixed Hemadsorption Assay for Detection of Cell Surface Binding Anti-tumor Antibodies in Human Sera“, J Immunol Methods, 261, 119-127 (January 2002)
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International Books and Book Chapters

  • Herlyn, D., B. Birebent, N. Akis, E. Purev, R. Somasundaram, E. Mitchell, H. Maguire, L. Staib, M. Mastrangelo, “Colon Cancer Antigen and Anti-Idiotype Vaccines“, Cancer Chemotherapy & Biological Response Modifiers Annual 21, ed. G. Giaccone, R. Schilsky, P. Sondel, Vol. 21, 287-298, Elsevier B.V., Oxford (January 2003)
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National Articles

  • Yurdakul S, N Akis, S Findik, “Transition to Adaptive Immunity”, Turkish Journal of Immunology, 11, 17-26 (January 2006)
  • Akış N, O. Sayhan, A. Karaçavuş, K. Töreci, “Immunogenicity and Specificity of Salmonella typhimurium Outer Membrane Antigens“, J Cell Mol Biol, 2:91-96 (January 2003)
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  • Türkoğlu S, A.P. Çamurdan, N. Akış, S. Badur, “İstanbul’da Rotavirus Çocuk Diyareleri Epidemiyolojisinin Virus Genom RNA’sı Elektroforezi ile Araştırılması“, Mikrobiyoloji Bulteni, 27, 93-99 (January 1993)
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  • Akış N, S. Badur, “Detection of Specific Antibodies in Enterobacterial Infections by Enzyme-immune-assay“, İnfeksiyon Dergisi, 4, 533-539 (January 1990)
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  • Badur S, N. Akış, A. Öztoprak, G. Çelik, M. Bayık, N. Uras, “İstanbul'da Hayat Kadınları, Eşcinseller ve Hastane Çalışanlarında Hepatit B ve HIV İnfeksiyonları Prevalansı“, Türk Mikrobiyoloji Cemiyeti Dergisi, 16, 135-146 (January 1986)
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National Conferences and Symposiums

  • PRESIDENT: Turkish Society for Immunology XII. Regional Symposium: Immunology School (2017). • • • SPEAKER: TİD-İO (2017). National Immunology Congress (2007-2013). CCE-İB-Biochemistry Days (2011). TÜBİTAK-MAM-GMBEA Seminars (2004-2006). Haliç Üniv. MBG Spring Symp. (2008) (October 2017)

National Books and Book Chapters

  • N. Akış. Rotavirüs İmmünolojisi. Kitap: Viral İmmünoloji, Ed. ET Çetin. 1989, Anadolu Üniversitesi Basımevi, Eskişehir, s 51-57 (October 1989)

Doctoral Dissertations Advised

  • Immunology PhD Programme: Dilek Tiyekli, BSc, MA (June 2016)
  • Medical Microbiology Residency Programme: Demirhan Güven, MD (April 2012)

Master`s Theses Advised

  • Immunology MSc Programme: Behzat Hashemzadeh, BA (October 2018)
  • Medical Microbiology MSc Programme: Samet Alboy, BSc (October 2012)

Editorial Positions

  • ORPHEUS/AMSE/WFME Task Force: Deckert J, Gordon D, Karle H, Lackovic Z, Lindgren S, Millan LM, et al. Standards for PhD Education in Biomedicine and Health Sciences in Europe. [Internet]. Available from, https://orpheus-med.org/wp-content/uploads/2021/11/ORPHEUS-AMSE-WFME-standards-for-PhD-education.pdf. Translation: Say A, Güç D, Tiyekli D, İlhan F, Araslı M, Akış N). Avrupa'da Biyotıp ve Sağlık Bilimlerinde PhD Eğitim Standartları. N Akış (ed). [Internet]. Zagreb, Hırvatistan: ORPHEUS; 2013 [accessible at Jan 9, 2024]. Available from, https://orpheus-med.org/wp-content/uploads/2021/11/ORPHEUS-AMSE-WFME_tur.pdf (see below for Biyotıp PhD ORPHEUS Standartları.pdf) (January 2013)
  • N Akış. Klinik İmmunoloji Laboratuvar Föyleri. İstanbul Üniversitesi İmmünoloji Grubu Kitapçığı, İstanbul (May 1994)
  • Immunology Bultein, Editor (1991-1996), University of İstanbul Immunology Graduate Group and Turkish Society for Immunology Joint Publication, Istanbul >>> Turkish Journal of Immunology, Assistant Editor (1996-2004) and Advisory Board Member (2021-2023), The Official Journal of The Turkish Society of Immunology, Istanbul

Referee Positions

  • ARTICLE: TMSJ (2023), TJI (2017-2021), Microbiological Research (2017), Balkan Medical Journal (2012-2014), JCMB (2004-2005) • • • GRANT: TÜBİTAK reviewer-moderator (2008, 2018, 2020-2022), Akdeniz Univ Project Fund (2013), TÜBAP (2008).

Projects

  • Study Of Cytotoxic CD4+ T Lymphocytes and Stress Proteins in Blood of Patients Suffering from Inflammatory Diseases and Immunodeficiency Syndromes (MSc education and thesis supervisor, TÜBAP) (December 2019)
  • Mononuclear Cell Binding and Protective Gene Expression Patterns of Endothelial Cells in Response to Insults of Different Types of Diabetes (PhD mentor and dissertation supervisor, TÜBAP) (June 2016)
  • Controlling Atheroprotective Gene Expression by Controlling Expression of Its Specific miRNAs (Research supervisor for a research bursary holder, EFIS • • • Sabbatical bursar, YÖK) (February 2013)
  • Analysis of Staphylococcus aureus' Response Following Exposition of Bacteria to Vancomycin and Meticilline (MSc education and thesis supervisor, TÜBAP) (October 2012)
  • Electrophoretic Typing of Stress Response of Salmonella (Medical Microbiology Residency Program thesis supervisor, TÜBAP) (April 2012)
  • CRISPR repertoire of Salmonella typhimurium LT2 (PI) (February 2012)
  • Protective Gene Expression in Diabetic Endothelial Dysfunction (Mentor and research supervisor for a postdoctoral bursary holder, TÜBİTAK) (January 2010)
  • Examination of Anti-apoptotic Response of Endothelial Cells by Fluorescence Microscopy Following Exposition of The Cells to High Concentration of D-Glucose and Insulin (PI: 2006 Haliç Unv. BAP – 2015 TÜBAP) (September 2006)
  • Molecular Mechanism of Renal Injury (Postdoctoral fellow, NIH-RTG 5T32DK007006-29) • • • Molecular Mechanism of Renal Inflammation and Injury (Postdoctoral fellow, NIH-CG 5P50DK045191-10) • • • Immunologic Mechanism of Lupus Nephritis (Postdoctoral fellow, NIH-5RO1DK33694-18) (September 2002)
  • Monoclonal Anti-idiotype Antibody Against Colorectal Cancer (Postdoctoral trainee, NIH-3RO1CA060975-03S1; and Postdoctoral bursar, NATO-TÜBİTAK-B1) • • • Recombinant Antigen Vaccines (Postdoctoral trainee, CA010815; and Postdoctoral bursar, NATO-TÜBİTAK-B1) (March 1998)
  • B Cell Differentiation in Ig Transgenic Mice (Postdoctoral trainee, NIH-5RO1CA004946-35; and Postdoctoral bursar, NATO-TÜBİTAK-B1) (March 1997)
  • Effect of Bradykinin To Endothelial cells-Blood Cells Interactions In Models of Diabetes (PhD dissertation, Istanbul Univ. BAP) (September 1996)
  • Developing Anti-idiotypic Antibody, Which Mimics Receptor Binding Site of Hepatitis B Virus (Predoctoral student research bursar, France Government Scholarship) (August 1992)
  • Studying Antigenic Properties of S. typhimurium OMP by ELISA (MSc thesis, Istanbul SOM Div. Microbiology Fund) (September 1989)

Certificates

  • Homogenous mouse glomerular endothelial (Penn Docket 02748-1), renal mesengial (Penn Docket 02748-2), and glomerular visceral epitelial (Penn Docket 02748-3) cell lines; University of Pennsylvania- Center for Technology Transfer, 2001, Philadelphia (September 2001)

Other

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» Courses Given

Medical Microbiology Residency Program and Fellowship

PhD and MSc Programs (in Immunology, in Medical Microbiology)

Undergraduate MD Program: Immunobiology, Immune Physiopathology

» Announcements

10 April 2015 » Postdoctoral Training in Immunology