» Publications

SCI-SSCI or SCI Expanded Articles

.DÖNMEZ AYDIN DIDEM, TASKINALP OGUZ, ULUÇAM ENIS, KARADAG ÇETIN HAKAN, KIZILAY ÖZFIDAN GÜLNUR, TOPUZ RUHAN DENIZ, ERSOY ONUR, The Effect of Acute and Chronic Formaldehyde Exposure on Learning and Memory in Male and Female Rats, International Journal of Neuroscience, 2024.

.GÜNDÜZ ÖZGÜR, YURTGEZEN ZEKIYE GÜLFEM, TOPUZ RUHAN DENIZ, SAPMAZ METIN MELIKE, KAYA OKTAY, ORHAN ABDULLAH ERKAN, ULUGÖL AHMET, The therapeutic effects of transferring remote ischemic preconditioning serum in rats with neuropathic pain symptoms, Heliyon Elsevier BV, vol. 9, no. 10, 2023. (October 2023)

Effect of chronic physiological stress on rat oocyte reserve: Role of IGF-1, AMH and Bcl-2 (June 2023)

.TOPUZ RUHAN DENIZ, GÖRGÜLÜ YASEMIN, ULUTÜRK MILKIBAR KYAZIM, Could serum endocannabinoid and N-acylethanolamine levels be important in bipolar disorder?, the world journal of biological psychiatry, 2023. (April 2023)

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.GÜNDÜZ ÖZGÜR, SAPMAZ METIN MELIKE, TOPUZ RUHAN DENIZ, KAYA OKTAY, ULUGÖL AHMET, KARADAG ÇETIN HAKAN, Anti-Inflammatory and Antipruritic Effects of Remote Ischaemic Postconditioning in a Mouse Model of Experimental Allergic Contact Dermatitis, MDPI AG, vol. 59, 2023.

.GÜVEN SELIS GÜLSEVEN, ERSOY ONUR, TOPUZ RUHAN DENIZ, BULUT ERDOGAN, KIZILAY ÖZFIDAN GÜLNUR, UZUN CEM, Does Oral Monosodium Glutamate Have a Cochleotoxic Effect? An Experimental Study, Audiology and Neurotology, 2022.

.TOPUZ RUHAN DENIZ, ÇETINKAYA MEHMET ZAHID, ERÜMIT Dilsat, DUVAN AYDEMIR KÜBRA, GÜNDÜZ ÖZGÜR, KARADAG ÇETIN HAKAN, ULUGÖL AHMET, The role of endocannabinoid system and TRPV1 receptors in the antidepressant and anxiolytic effects of dipyrone in chronic unpredictable mild stress in mice, European Journal of Pharmacology, vol. 908, pp. 174315, 2021. (October 2021)

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The Role of Hydrogen Sulfide in the Development of Tolerance and Dependence to Morphine in Mice, Neuropsychobiology, 11, 2020. (November 2020)

.D. R. TOPUZ, Ö. GÜNDÜZ, H. Ç. KARADAG, A. ULUGÖL, Non-opioid Analgesics and the Endocannabinoid System, Balkan Medical Journal, 10, 2020. (October 2020)

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A story of the potential effect of non-steroidal anti-inflammatory drugs (NSAIDs) in Parkinson's disease: beneficial or detrimental effects (April 2023)
Isobolographic analysis of antinociceptive effect of ketorolac, indomethacin, and paracetamol after simultaneous peripheral local and systemic administration
The Analgesic Dipyrone Affects Pregnancy Outcomes and Endocrine-Sensitive Endpoints in Female and Male Offspring Rats
Activation of Peripheral Cannabinoid Receptors Synergizes the Effect of Systemic Ibuprofen in a Pain Model in Rat
Pain management strategies in urethral reconstruction: a narrative review
The role of endocannabinoid system and TRPV1 receptors in the antidepressant and anxiolytic effects of dipyrone in chronic unpredictable mild stress in mice
Uterotrophic and in vitro screening for (anti)estrogenic activity of dipyrone
Endogenous opioid and cannabinoid systems contribute to antinociception produced by administration of NSAIDs into the insular cortex of rats (November 2020)

Endocannabinoid and N-acylethanolamide levels in rat brain and spinal cord following systemic dipyrone and paracetamol administration, Canadian Journal of Physiology and Pharmacology, vol. 97, no. 11, pp. 1035-1041, 11, 2019. (July 2019)

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.M. AKINCI, H. Ç. KARADAG, S. CHOUSEIN-HÜSEYIN, Ç. OLTULU, S. CANBAZ, Ö. GÜNDÜZ, D. R. TOPUZ, Effects of in vitro Amitriptyline, Fluoxetine,Tranylcypromine and Venlafaxine on SaphenousVein Grafts, Brazilian Journal of Cardiovascular Surgery, vol. 34, no. 3, pp. 290-296, 1, 2019. (July 2019)

.D. R. TOPUZ, Ö. GÜNDÜZ, E. TASTEKIN, H. Ç. KARADAG, Effects of hippocampal histone acetylation and HDAC inhibition on spatial learning and memory in the Morris water maze in rats, Fundamental Clinical Pharmacology, vol. 34, no. 2, pp. 222-228, 4, 2020. (April 2019)

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An enriched environment improves maternal sleep deprivation-induced cognitive deficits and synaptic plasticity via hippocampal histone acetylation (June 2023)
Elaboration of the Effective Multi-Target Therapeutic Platform for the Treatment of Alzheimer's Disease Based on Novel Monoterpene-Derived Hydroxamic Acids (June 2023)
Ginsenoside Rg1 attenuates cerebral ischemia-reperfusion injury through inhibiting the inflammatory activation of microglia (May 2023)
Celastrus paniculatus oil ameliorates NF-KB mediated neuroinflammation and synaptic plasticity in the scopolamine-induced cognitive impairment rat model (April 2023)
Role of miR-219a-5p in regulating NMDAR in nonylphenol-induced synaptic plasticity damage (March 2023)
Beneficial Effects of Tofacitinib in Long-Standing Diabetes-Induced Cognitive Impairment in Rats through BDNF-TNF-alpha-Nrf2 Signalling Pathway Fan, SB and Song, R
The role of the gut microbiota and nutrition on spatial learning and spatial memory: a mini review based on animal studies
Dapagliflozin diminishes memory and cognition impairment in Streptozotocin induced diabetes through its effect on Wnt/beta-Catenin and CREB pathway
Prenatal morphine exposure increases gamma oscillation and theta coherence in the rat reward system
Inhibiting Microglia-Derived NLRP3 Alleviates Subependymal Edema and Cognitive Dysfunction in Posthemorrhagic Hydrocephalus after Intracerebral Hemorrhage via AMPK/Beclin-1 Pathway
Radix polygoni multiflori protects against hippocampal neuronal apoptosis in diabetic encephalopathy by inhibiting the HDAC4/JNK pathway
Gut Microbiota-Derived Short-Chain Fatty Acids: Impact on Cancer Treatment Response and Toxicities
Inhibition of Histone Deacetylase 6 (HDAC6) as a therapeutic strategy for Alzheimer's disease: A review (2010-2020)
CREB1(K292) and HINFPK330 as Putative Common Therapeutic Targets in Alzheimer's and Parkinson's Disease
Mechanisms of Short-Chain Fatty Acids Derived from Gut Microbiota in Alzheimer's Disease
Sirtuins, Mitochondria and the Melatonergic Pathway in Alzheimer’s Disease (February 2020)

.M. KUZUCUOGLU, D. R. TOPUZ, E. ALTUN, Effect of mitomycin-C applied through different approachesfollowing tracheal surgery on development of granulation tissueand level of nephrotoxicity in rats, Turk Gogus Kalp Damar Cerrahisi Dergisi-Turkish Journal of Thoracic and Cardiovascular Surgery, vol. 27, no. 1, pp. 73-79, 1, 2019. (January 2019)

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Changes in nociceptin/orphanin FQ levels in rat brain regions after acute and chronic cannabinoid treatment in conjunction with the development of antinociceptive tolerance (December 2016)

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ATIFLAR

A Crosstalk between the Cannabinoid Receptors and Nociceptin Receptors in Colitis-Clinical Implications
Sitagliptin and fucoidan prevent apoptosis and reducing ER stress in diabetic rat testes
The Role of Hydrogen Sulfide in the Development of Tolerance and Dependence to Morphine in Mice (October 2020)
Role of Nitric Oxide in the Antipruritic Effect of WIN 55,212-2, a Cannabinoid Agonist (June 2020)
Endogenous Opiates and Behavior: 2016
Spinal Serotonin and 5HT6 Receptor Levels During Development of Neuropathy and Influence of Blockade of these Receptors on Thermal Hyperalgesia in Diabetic Mice
Endocannabinoid and N-acylethanolamide levels in rat brain and spinal cord following systemic dipyrone and paracetamol administration

International Articles

.GUR GAMZE, TOPUZ RUHAN DENIZ, KIZILAY ÖZFIDAN GÜLNUR, The Effect of Ceftriaxone in Valproic Acid-Induced Mouse Model of Autism, Advanced Pharmaceutical Bulletin, 2022.

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.AKBAS Sedef, TOPUZ RUHAN DENIZ, The role of neurotensin receptor 1 on fear memory in mice, Journal of Research in Pharmacy, vol. 25, no. 5, pp. 609-615, 2021.

.B. CHATZISALI, T. GAS, H. KILGIN, K. A. DUVAN, D. ERÜMIT, D. R. TOPUZ, A. ULUGÖL, CANNABINOID RECEPTORS ARE NOT INVOLVED IN ANTINOCICEPTION INDUCED BY SYSTEMIC DICLOFENAC IN MICE, Turkish Medical Student Journal, vol. 7, no. 1, pp. 1-4, 2, 2020.

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Does dipyrone produce anxiolytic-like effects in mice? (October 2019)
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ATIFLAR
- A Rare Case of Intravenous Metamizole Abuse
- The role of endocannabinoid system and TRPV1 receptors in the antidepressant and anxiolytic effects of dipyrone in chronic unpredictable mild stress in mice
- Non-opioid Analgesics and the Endocannabinoid System

International Conference Proceedings

DENEYSEL ALERJİK KONTAKT DERMATİT FARE MODELİNDE UZAK İSKEMİK ART KOŞULLANMANIN ANTİİNFLAMATUVAR VE ANTİPRURİTİK ETKİSİ (November 2023)

The role of endocannabinoid system and TRPV1 receptors in the antidepressant and anxiolytic effects of dipyrone in chronic unpredictable mild stress in mice (October 2021)

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.D. R. TOPUZ, Ö. GÜNDÜZ, D. DÖKMECI, H. Ç. KARADAG, A. ULUGÖL, Does dipyrone produce anxiolytic-like effects in mice?, FENS Regional Meeting 2019. Belgrade, Serbia.. (July 2019)

Endocannabinoid and N-acylethanolamide levels in rat brain and spinal cord following systemic dipyrone and paracetamol administration, Pain in Europe XI, 11th Congress of the European Pain Federation EFIC. Valencia, SPAIN, -İSPANYA (June 2019)

.D. R. TOPUZ, The attitudes and behaviors of the physicians in thefamily health centers of Edirne province, on rational druguse and adverse effects, 8. International Trakya Family Medicine Congress, edirne-TÜRKIYE. (March 2019)

.S. YILMAZ, D. R. TOPUZ, Ö. GÜNDÜZ, D. DÖKMECI, A. ULUGÖL, H. Ç. KARADAG, Effect Of The Nociceptin Receptor Antagonist Jtc-801 On Chronic Win 55,212-2 Induced Changes In Contextual Fear Conditioning In Mice, Union of Thrace Universities 2 nd International Health Sciences Congress, TEKIRDAG-TÜRKIYE.

.Ö. E. ÖZGÜR, E. BAKSIN, H. DEMIREL, D. R. TOPUZ, A. ULUGÖL, Systemic cannabidiol does not reduce compound 48/80-induced itching behavior in mice, Union of Thrace Universities 2nd International Health Sciences Congress.

EFFECT OF MITOMYCIN-C APPLIED THROUGH DIFFERENT APPROACHES FOLLOWING TRACHEAL SURGERY ON DEVELOPMENT OF GRANULATION TISSUE AND LEVEL OF NEPHROTOXICITY IN RATS, Association of thrace of universities 1st international health science congres. (November 2017)

Effects of resveratrol on glycerol-induced myoglobirnuric kidney injury, Association of thrace of universities 1st international health science congres.

The effecsts of in-vitro used amitriptyline ,fluoxetine tranylcpromine and venlafaxine on saphenous vein grafts that are oftenly used in coronary artery bypass surgery, Association of thrace of universities 1st international health science congres.

EFFECT OF HIPOCAMPAL HISTONE ACETYLATION AND HDAC INHIBITION ON SPATIAL LEARNING AND MEMORY IN THE MORRISWATER MAZE IN RATS (June 2016)

International Books and Book Chapters

.TOPUZ RUHAN DENIZ, Temel ve Klinik Farmakoloji, Nobel Tip Kitabevleri, istanbul-TÜRKIYE.
.TOPUZ RUHAN DENIZ, ULUGÖL AHMET, Temel ve Klinik Farmakoloji, Nobel Tip Kitabevleri, istanbul-TÜRKIYE.

National Articles

FARELERDE SKOPOLAMİNLE BOZULMUŞ ÖĞRENME VE BELLEK ÜZERİNE NÖROTENSİN AGONİSTİ PD149163’ÜN ETKİSİ

.D. R. TOPUZ, Kannabinoidlerin Farmakolojisi, TÜRKIYE KLINIKLERI, vol. 6, no. 1, pp. 6-14, 1, 2018.

National Conference Proceedings

ÖĞRENME VE BELLEK YAPILANMASINDA RESVERATROLÜN KUŞAKLARARASI DAVRANIŞSAL ETKİLERİ (November 2023)
RHO/RHO-KİNAZ YOLAĞININ BAĞLAMSAL KORKU KOŞULLANMADAKİ ROLÜ (November 2023)

D. R. TOPUZ, Ö. GÜNDÜZ, H. Ç. KARADAĞ, D. DÖKMECİ, A. ULUGÖL, Akut Sistemik Dipiron ve Parasetamol Uygulamasının Sıçan Beyin Bölgelerinde ve Omurilikte Endokannabinoid ve NAçiletanolamin düzeylerine etkisi, 25.Ulusal Farmakoloji Kongresi, AYDIN-TÜRKİYE (November 2019)

D. R. TOPUZ, M. M. SAPMAZ, G. Z. YURTSEVEN, K. A. DUVAN, İntrauterin dönemde valproik aside maruz kalan dişi farelerin beyninde östrojen reseptör alfa’nın dağılımı ve davranışsal değişiklikler, 24. Ulusal Elektron Mikroskopi Kongresi (Uluslararası katılımlı), EDİRNE-TÜRKİYE (November 2019)

Z. ÇETİN, Ö. GÜNDÜZ, D. R. TOPUZ, D. DÖKMECİ, H. Ç. KARADAĞ, A. ULUGÖL, Farelerde Morfine Tolerans ve Bağımlılık Gelişiminde Hidrojen Sülfürün Rolü, 25.Ulusal Farmakoloji Kongresi, AYDIN-TÜRKİYE (November 2019)

D. R. TOPUZ, Ö. GÜNDÜZ, D. DÖKMECİ, H. Ç. KARADAĞ, A. ULUGÖL, Dipiron farelerde anksiyolitik-benzeri etkiler oluşturuyor mu?, 25.Ulusal Farmakoloji Kongresi, AYDIN-TÜRKİY (November 2019)

G. GÜR, D. R. TOPUZ, G. Ö. KIZILAY, Farelerde Valproik Asit İle Oluşturulan Otizm Modelinde Seftriaksonun Etkisi, 25.Ulusal Farmakoloji Kongresi, AYDIN-TÜRKİYE (November 2019)

S. AKBAŞ, D. R. TOPUZ, Nörotensinin farelerde ipuçlu ve bağlamsal korku koşullanma üzerine etkisi, 25.Ulusal Farmakoloji Kongresi, AYDIN-TÜRKİYE (November 2019)

D. R. TOPUZ, Ö. GÜNDÜZ, G. E. ÜMİT, Ö. SEZER, K. TABAKÇIOĞLU, O. KAYA, D. Y. HAN, M. GÜNEŞ, Trakya Üniversitesi Tıp Fakültesi ‘Akılcı İlaç Kullanımı’xx Eğitimi Öğrenci Geribildirimleri, Ulusal Tıp Eğitimi Sempozyumu, eskişehir-TÜRKİYE (April 2019)

National Books and Book Chapters

A.ULUGÖL, ÇH. KARADAĞ, D. DÖKMECİ, Ö. GÜNDÜZ, RD. TOPUZ, Farmakoloji, Nobel Tıp Ktabevleri, İstanbul, 2017 (September 2017)

.D. R. TOPUZ, Farmakoloji, Ulusal, Bölüm: Antikanser ilaçlar, Basim Türü: Basili, TÜRKIYE-, Nobel tip kitabevi, 20171. Basim. (September 2017)

.D. R. TOPUZ, Farmakoloji, Ulusal, Bölüm: Antiepileptik ilaçlar, Basim Türü: Basili, pp. 115-223, TÜRKIYE-, Nobel tip kitabevi, 20171. Basim. (September 2017)

.D. R. TOPUZ, Farmakoloji, Ulusal, Bölüm: Otakoidler, Basim Türü: Basili, pp. 195-205, TÜRKIYE-, Nobel tip kitanbevi, 20171. Basim. (September 2017)

.D. R. TOPUZ, Farmakoloji, Ulusal, Bölüm: Vitaminler, Basim Türü: Basili, pp. 351-357, TÜRKIYE-, Nobel tip kitabevi, 20171. Basim. (September 2017)

.D. R. TOPUZ, Farmakoloji, Ulusal, Bölüm: Antifungal ilaçlar, Basim Türü: Basili, pp. 317-323, TÜRKIYE-, Nobel Tip Kitabevi, 20171. Basim. (September 2017)

.D. R. TOPUZ, Farmakoloji, Ulusal, Bölüm: Antiparaziter ilaçlar, Basim Türü: Basili, pp. 323-331, TÜRKIYE-, Nobel Tip Kitabevi, 20171. Basim. (September 2017)

.D. R. TOPUZ, Farmakoloji, Ulusal, Bölüm: Immünomodülatör ilaçlar, Basim Türü: Basili, pp. 339-345, TÜRKIYE-, Nobel Tip Kitabevi, 20171. Basim. (September 2017)

.D. R. TOPUZ, Farmakoloji, Ulusal, Bölüm: Antiviral ilaçlar, Basim Türü: Basili, pp. 331-339, TÜRKIYE-, Nobel tip kitabevi, 20171. Basim. (September 2017)

.D. R. TOPUZ, Farmakoloji, Ulusal, Bölüm: Antiseptikler ve Dezenfektanlar, Basim Türü: Basili, pp. 345-351, TÜRKIYE-, Nobel Tip Kitabevi, 20171. Basim. (September 2017)

.D. R. TOPUZ, Farmakoloji, Ulusal, Bölüm: Kalsiyotropik ilaçlar, Basim Türü: Basili, pp. 243-249, TÜRKIYE-, Nobel Tip Kitabevi, 20171. Basim. (September 2017)

Master`s Theses Advised

Rho/Rho kinaz yolağının bağlamsal korku koşullanmadaki rolü
Farelerde Valproik Asit İle Oluşturulan Otizm Modelinde Seftriaksonun Etkisi (April 2019)
Nörotensinin farelerde ipuçlu ve bağlamsal korku koşullanma üzerine etkisi (April 2019)

Referee Positions

The Sirtuin 2 Inhibitor AK-7 Leads to an Antidepressant-Like Effect in Mice via Upregulation of CREB1, BDNF, and NTRK2 Pathways

The effect of prenatal zonisamide exposure on motor and cognitive functions of rats" (June 2017)

Projects

Memantin türevi 3 farklı yeni molekülün farelerde bağlamsal korku koşullanma testinde bellek üzerine etkileri

Öğrenme ve bellek yapılanmasında resveratrolun kuşaklararası epigenetik etkilerinin değerlendirilmesi

Sıçanlar arasında serum yoluyla taşınan uzak iskemik ön koşullanmanın nöropatik ağrı belirtilerini tedavi edici etkisi

.Unipolar Mani ve Bipolar Bozukluk Hastalarinin Serum Endokannabinoid Seviyelerinin karsilastirilmasi, 2022.

Kronik öngörülemeyen hafif strese maruz kalan farelerde dipironun antidepresan ve anksiyolitik etkisinde kannabinoid sistemin rolü

Glikojen sentaz kinaz-3β enzim inhibitörü TC-G24'ün akut immobilizasyon stresi üzerine olası rolü

Monosodyum Glutamat’ın Kokleotoksik Etkisinin Guinea Piglerde Araştırılması, Monosodyum Glutamat’ın Kokleotoksik Etkisinin Guinea Piglerde Araştırılması (December 2020)

Farelerde Valproik Asit İle Oluşturulan Otizm Modelinde Seftriaksonun Etkisi

.Yüksekögretim Kurumlari tarafindan destekli bilimsel arastirma projesi, Akut sistemik dipiron ve parasetamol uygulamasinin siçan beyin bölgelerinde ve omurilikte endokannabinoid ve N-açiletanolamin düzeylerine etkisi, Akut sistemik dipiron ve parasetamol uygulamasinin siçan beyin bölgelerinde ve omurilikte endokannabinoid ve N-açiletanolamin düzeylerine etkisi, Baslangiç Tarihi: 14.02.2018, Bitis Tarihi : ,Kurumu: TRAKYA ÜNIVERSITESI, Devam Ediyor.

.Yüksekögretim Kurumlari tarafindan destekli bilimsel arastirma projesi, Nörotensinin farelerde ipuçlu ve baglamsal korku kosullanma üzerine etkisi, Nörotensinin farelerde ipuçlu ve baglamsal korku kosullanma üzerine etkisi, Baslangiç Tarihi: 28.03.2018, Bitis Tarihi : ,Kurumu: TRAKYA ÜNIVERSITESI, Devam Ediyor.

Other

Klinik araştırmalar etik kurulu üyeliği (August 2023)
temel hekimlik uygulaması (oral,rektal, vajinal ilaç uygulama)
temel hekimlik uygulama kılavuzu (uygulanacak ilacın hazırlanması)
Bilimsel araştırmalar etik kurul üyeliği
Bilimsel araştırmalar etik kurul üyeliği
Bilimsel etik kurul üyeliği

» Educational Qualifications

Bachelor`s Degree » Graduated in 2005

Doctoral Degree » Graduated in 2015

» Publications

SCI-SSCI or SCI Expanded Articles

International Articles

International Conference Proceedings

International Books and Book Chapters

National Articles

National Conference Proceedings

National Books and Book Chapters

Master`s Theses Advised

Referee Positions

Projects

Other