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SCI-SSCI or SCI Expanded Articles

Association Between Plasma Asprosin Levels and Gestational Diabetes Mellitus. Diabetes Metabolic Syndrome and Obesity.Boz İB, Aytürk Salt S, Salt Ö, Sayın NC, Dibirdik İ. Diabetes Metab Syndr Obes. 2023; 16: 2515–2521. doi: 10.2147/DMSO.S424651. (August 2023)

A novel biomarker in acute cholecystitis: YKL-40. E. Çeliktürk, Salt, M.B. Sayhan, I. Dibirdik. Asian Journal of Surgery. 2023 Apr;46(4):1564-1570. https://doi.org/10.1016/j.asjsur.2022.09.073 (April 2023)

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The synergistic anticancer effect of salinomycin combined with cabazitaxel in CD44+ prostate cancer cells by downregulating wnt, NF-κB and AKT signaling. Erdogan, S., Serttas, R., Turkekul, K., Dibirdik, I. Mol Biol Rep 49, 4873–4884 (2022). https://doi.org/10.1007/s11033-022-07343-y. (June 2022)

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Midkine silencing enhances the anti-prostate cancer stem cell activity of the flavone apigenin: cooperation on signaling pathways regulated by ERK, p38, PTEN, PARP, and NF-κB. Erdogan S, Turkekul K, Dibirdik I, Doganlar ZB, Doganlar O, Bilir A. Invest New Drugs. 2019 Apr 16. doi: 10.1007/s10637-019-00774-8. (April 2019)

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Moslehi M, Rezaei S, Talebzadeh P, et al. Apigenin in cancer therapy: Prevention of genomic instability and anticancer mechanisms. Clin Exp Pharmacol Physiol. 2023;50(1):3‐18. doi:10.1111/1440-1681.13725 (October 2023)
Al-Rashidi RR ve ark. Malignant function of nuclear factor-kappaB axis in prostate cancer: Molecular interactions and regulation by non-coding RNAs. Pharmacological Research 194 (2023) 106775. https://doi.org/10.1016/j.phrs.2023.106775 (August 2023)
Ghanbari-Movahed, M.; Shafiee, S.; Burcher, J.T.; Lagoa, R.; Farzaei, M.H.; Bishayee, A. Anticancer Potential of Apigenin and Isovitexin with Focus on Oncogenic Metabolism in Cancer Stem Cells. Metabolites 2023, 13, 404. https://doi.org/10.3390/metabo13030404. (March 2023)
Pratibha Pandey, Fahad Khan, Tarun Kumar Upadhyay. Deciphering the modulatory role of apigenin targeting oncogenic pathways in human cancers. Chem Biol Drug Des. 2023;101:1446–1458. https://doi.org/10.1111/cbdd.14206 (February 2023)
Amini P ve ark. Induction of Cancer Cell Death by Apigenin: A Review on Different Cell Death Pathways. Mini-Reviews in Medicinal Chemistry 23, Issue 14, 2023 Page: [1461 - 1478]. DOI: 10.2174/1389557523666230119110744 (January 2023)
Masoud Moslehi, Sepideh Rezaei, Pourya Talebzadeh, Mohammad Javed Ansari, Mohammed Abed Jawad, Abduladheem Turki Jalil, Nima Rastegar-Pouyani, Emad Jafarzadeh, Shahram Taeb, Masoud Najafi. Apigenin in cancer therapy: Prevention of genomic instability and anticancer mechanisms. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY. Volume50, Issue1 January 2023 Pages 3-18. https://doi.org/10.1111/1440-1681.13725 (January 2023)
Targeting cancer stem cells by nutraceuticals for cancer therapy. Man Chu, Cheng Zheng, Cheng Chen, Gendi Song, Xiaoli Hu, Zhi-wei Wang. Seminars in Cancer Biology 85, 2022, 234-245. https://doi.org/10.1016/j.semcancer.2021.07.008. (October 2022)
Fatih Genc, Ugur Simal Atabey, Riza Serttas and Suat Erdogan*. Abiraterone Acetate, in Combination with Apigenin, Attenuates the Survival of Human Castration-Sensitive Prostate Cancer Cells. Anti-Cancer Agents in Medicinal Chemistry. Volume 22, Issue 18, 2022 Published on: 02 August, 2022 Page: [3148 - 3156] DOI: 10.2174/1871520622666220426095257 (August 2022)
Marek Moczulski, Angelika Artelska, Prof. Dr. Łukasz Albrecht, Dr. Anna Albrecht. Photocatalytic Activity of Triphenylphosphine and Potassium Iodide System in the Decarboxylative Alkylation of 3-Cyanochromones. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. Volume2022, Issue31, e202200630 August 19, 2022. https://doi.org/10.1002/ejoc.202200630 (August 2022)
Gilles Tossing, Raphaël Livernoche, Claudia Maios, Constantin Bretonneau, Audrey Labarre and J. Alex Parker. Genetic and pharmacological PARP inhibition reduces axonal degeneration in C. elegans models of ALS. Human Molecular Genetics, 2022, Vol. 31, 19, 3313–3324. https://doi.org/10.1093/hmg/ddac116 (June 2022)
Zhang, L., Song, L., Xu, Y. et al. Midkine promotes breast cancer cell proliferation and migration by upregulating NR3C1 expression and activating the NF-κB pathway. Mol Biol Rep 49, 2953–2961 (2022). https://doi.org/10.1007/s11033-022-07116-7 (May 2022)
Construction of trisubstituted chromone skeletons carrying electron-withdrawing groups via PhIO-mediated dehydrogenation and its application to the synthesis of frutinone A. Li, Q., Zhuang, C., Wang, D., Zhang, Y., Du, Y. Beilstein Journal of Organic Chemistry, 2019, 15 (12): 2958-2965. (December 2019)

Midkine downregulation increases the efficacy of quercetin on prostate cancer stem cell survival and migration through PI3K/AKT and MAPK/ERK pathway. Erdogan S, Turkekul K, Dibirdik I, Doganlar O, Doganlar ZB, Bilir A, Oktem G. Biomed Pharmacother. 2018 Nov;107:793-805. doi: 10.1016/j.biopha.2018.08.061. Epub 2018 Aug 22. (December 2018)

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Georgiou, N.; Kakava, M.G.; Routsi, E.A.; Petsas, E.; Stavridis, N.; Freris, C.; Zoupanou, N.; Moschovou, K.; Kiriakidi, S.; Mavromoustakos, T. Quercetin: A Potential Polydynamic Drug. Molecules 2023, 28, 8141. https://doi.org/10.3390/molecules28248141. (December 2023)
Guo M ve ark. Research Progress on Quercetin’s Biological Activity and Structural Modification Based on Its Antitumor Effects. ChemistrySelect 2023, 8, e202303167 (1 of 16). doi.org/10.1002/slct.202303167. (November 2023)
Kam, N.-W.; Lau, C.-Y.; Che, C.-M.; Lee, V.H.-F. Nasopharynx Battlefield: Cellular Immune Responses Mediated by Midkine in Nasopharyngeal Carcinoma and COVID-19. Cancers 2023, 15, 4850. https://doi.org/10.3390/ cancers15194850. (October 2023)
Hashemi M ve ark. Targeting PI3K/Akt signaling in prostate cancer therapy. Journal of Cell Communication and Signaling (2023) 17:423–443. https://doi.org/10.1007/s12079-022-00702-1 (September 2023)
SHAO Xiangmin LI Ke FENG Shuang FENG Yali ZHAI Guangyu. Research Progress on Biological Function and Application of Quercetin in Animal Production. Feed Industry. 2023 Sep 1;44(17); 29-35. doi:10.13302/j.cnki.fi.2023.17.005. (June 2023)
Kaushik, A., Chauhan, K., Singh, S. Neuroprotective potential of quercetin as a nutraceutical targeting fused neuroinflammation in neurological disease (2023) Treatments, Nutraceuticals, Supplements, and Herbal Medicine in Neurological Disorders, pp. 623-637. (June 2023)
Saikia, M.; Cheung, N.; Singh, A.K.; Kapoor, V. Role of Midkine in Cancer Drug Resistance: Regulators of Its Expression and Its Molecular Targeting. Int. J. Mol. Sci. 2023, 24, 8739. https://doi.org/ 10.3390/ijms24108739. (May 2023)
Wei Fu ve ark. Based on Network Pharmacology-Quercetin, a Component of Fuzheng Yiliu Decoction Suppressed Prostate Cancer by Regulating PI3K/AKT Pathway. Andrologia Volume 2023, Article ID 1445953, 17 pages https://doi.org/10.1155/2023/1445953. (May 2023)
Mina Homayoonfal ve ark. Quercetin modulates signal transductions and targets non-coding RNAs against cancer development. Cellular Signalling 107 (2023) 110667. https://doi.org/10.1016/j.cellsig.2023.110667. (April 2023)
Aslani F, Afarin R, Dehghani Madiseh N, Beheshti Nasab H, Monjezi S, et al. Potentiation of Apoptotic Effect of Combination of Etoposide and Quercetin on HepG2 Liver Cancer Cells. Hepat Mon. 2023;23(1):e136194. https://doi.org/10.5812/hepatmon-136194. (April 2023)
DB Kundrapu, RR Malla. Advances in Quercetin for Drug-Resistant Cancer Therapy: Mechanisms, Applications, and Delivery Systems. Critical Reviews in Oncogenesis, 2023, 28(4) 15-26. DOI: 10.1615/CritRevOncog.2023049513. (March 2023)
Petri´c, T.; Sabol, M. Let’s Go 3D! New Generation of Models for Evaluating Drug Response and Resistance in Prostate Cancer. Int. J. Mol. Sci. 2023, 24, 5293. https://doi.org/10.3390/ijms24065293. (March 2023)
Costa AR ve ark. Bitter taste signaling in cancer. Life Sciences 315 (2023) 121363. https://doi.org/10.1016/j.lfs.2022.121363. (February 2023)
Dong Yang ve ark. High throughput-screening of native herbal compounds identifies taccaoside A as a cytotoxic compound that mediates RAS signaling in cancer stem cells. Phytomedicine, Volume 108, 2023, 154492, ISSN 0944-7113, https://doi.org/10.1016/j.phymed.2022.154492. (January 2023)
Jia, W.; Zhou, L.; Li, L.; Zhou, P.; Shen, Z. Nano-Based Drug Delivery of Polyphenolic Compounds for Cancer Treatment: Progress, Opportunities, and Challenges. Pharmaceuticals 2023, 16, 101. https://doi.org/10.3390/ph16010101. (January 2023)
Biswas, P.; Dey, D.; Biswas, P.K.; Rahaman, T.I.; Saha, S.; Parvez, A.; Khan, D.A.; Lily, N.J.; Saha, K.; Sohel, M.; et al. A Comprehensive Analysis and Anti-Cancer Activities of Quercetin in ROS-Mediated Cancer and Cancer Stem Cells. Int. J. Mol. Sci. 2022, 23, 11746. https://doi.org/10.3390/ijms231911746 (October 2022)
Erdogan, S., Serttas, R., Turkekul, K. et al. The synergistic anticancer effect of salinomycin combined with cabazitaxel in CD44+ prostate cancer cells by downregulating wnt, NF-κB and AKT signaling. Mol Biol Rep 49, 4873–4884 (2022). https://doi.org/10.1007/s11033-022-07343-y (September 2022)
Hao, Q.; Wu, Y.; Vadgama, J.V.; Wang, P. Phytochemicals in Inhibition of Prostate Cancer: Evidence from Molecular Mechanisms Studies. Biomolecules 2022, 12, 1306. https://doi.org/10.3390/biom12091306 (September 2022)
Oršoli ́c, N.; Jazvinš ́cak Jembrek, M. Molecular and Cellular Mechanisms of Propolis and Its Polyphenolic Compounds against Cancer. Int. J. Mol. Sci. 2022, 23, 10479. https://doi.org/10.3390/ijms231810479 (September 2022)
Sharma E, Attri DC, Sati P, Dhyani P, Szopa A, Sharifi-Rad J, Hano C, Calina D and Cho WC (2022) Recent updates on anticancer mechanisms of polyphenols. Front. Cell Dev. Biol. 10:1005910. doi: 10.3389/fcell.2022.1005910 (September 2022)
Zhang, L., Song, L., Xu, Y. et al. Midkine promotes breast cancer cell proliferation and migration by upregulating NR3C1 expression and activating the NF-κB pathway. Mol Biol Rep 49, 2953–2961 (2022). https://doi.org/10.1007/s11033-022-07116-7 (August 2022)
Mohsen Karami fath, Menooa Ebrahimi, Ehsan Nourbakhsh, Ahmad Zia Hazara, Ali Mirzaei, Saba Shafieyari, Azadeh Salehi, Mahsa Hoseinzadeh, Zahra Payandeh, Ghasem Barati. PI3K/Akt/mTOR signaling pathway in cancer stem cells, Pathology - Research and Practice, Volume 237, 2022, 154010, https://doi.org/10.1016/j.prp.2022.154010. (August 2022)
Asgharian, P., Tazekand, A.P., Hosseini, K. et al. Potential mechanisms of quercetin in cancer prevention: focus on cellular and molecular targets. Cancer Cell Int 22, 257 (2022). https://doi.org/10.1186/s12935-022-02677-w (August 2022)
Dongdong Lu ,Jianwei Shang , Xiping Guo ,and Yaosheng Zhang. Assessing the Mechanism of Action of “Fructus Ligustri Lucidi-Cuscutae Semen” in Prostate Cancer Treatment Using Network Pharmacology and Molecular Docking. Computational and Mathematical Methods in Medicine. Volume 2022, Article ID 7543619, https://doi.org/10.1155/2022/7543619 (August 2022)
Bakrim, S.; El Omari, N.; El Hachlafi, N.; Bakri, Y.; Lee, L.-H.; Bouyahya, A. Dietary Phenolic Compounds as Anticancer Natural Drugs: Recent Update on Molecular Mechanisms and Clinical Trials. Foods 2022, 11, 3323. https://doi.org/10.3390/foods11213323 (July 2022)
Barsha Deb and Nishant Thakur , Quercetin Nanoparticles- A Promising Approach to Cancer Treatment: A Review.(2022).Int. J. Life Sci. Pharma Res.12(6), P142-161. http://dx.doi.org/10.22376/ijpbs/lpr.2022.12.6.P142-161 (July 2022)
Fakhri S, Moradi SZ, Yarmohammadi A, Narimani F, Wallace CE and Bishayee A (2022) Modulation of TLR/NF-kB/NLRP Signaling by Bioactive Phytocompounds: A Promising Strategy to Augment Cancer Chemotherapy and Immunotherapy. Front. Oncol. 12:834072. doi: 10.3389/fonc.2022.834072 (June 2022)
Hashemi, M., Taheriazam, A., Daneii, P. et al. Targeting PI3K/Akt signaling in prostate cancer therapy. J. Cell Commun. Signal. (2022). https://doi.org/10.1007/s12079-022-00702-1 (June 2022)
Yang, C.; Mai, Z.; Liu, C.; Yin, S.; Cai, Y.; Xia, C. Natural Products in Preventing Tumor Drug Resistance and Related Signaling Pathways. Molecules 2022, 27, 3513. https://doi.org/10.3390/molecules27113513 (May 2022)
Guanzhen Wang, Yuanhui Wang, Liangliang Yao, et al. Pharmacological Activity of Quercetin: An Updated Review. Evidence-Based Complementary and Alternative Medicine Volume 2022, Article ID 3997190, https://doi.org/10.1155/2022/3997190 (May 2022)
Burak Dik*, Devran Coskun and Ayşe Er. Protective Effect of Nerium oleander Distillate and Tarantula cubensis Alcoholic Extract on Cancer Biomarkers in Colon and Liver Tissues of Rats with Experimental Colon Cancer. Anti-Cancer Agents in Medicinal Chemistry. Volume 22, Issue 10, 2022 Page: [1962 - 1969] DOI: 10.2174/1871520621666210903120253 (January 2022)
Fengyi Xiang, Yueqing Wang, Chunyu Cao, Qingyun Li, Hao Deng, Jun Zheng, Xiaowen Liu* and Xiao Tan*. The Role of Kallikrein 7 in Tumorigenesis. Current Medicinal Chemistry. Volume 29, Issue 15, 2022 Page: [2617 - 2631] DOI: 10.2174/0929867328666210915104537 (January 2022)
Precision Nutrition and Cancer Relapse Prevention: A Systematic Literature Review. Reglero, Clara; Reglero, Guillermo. NUTRIENTS 2019, 11 (11), Article Number: 2799. (November 2019)
The role of Midkine in tumor development and its application as biomarkers. HOU Sha-sha, LI Ning, MENG Zhao-wei, TAN Jian. Tianjin Med J, September 2019, Vol. 47 No. 9, 990-993. (September 2019)
Chemoprevention of Prostate Cancer by Natural Agents: Evidence from Molecular and Epidemiological Studies. Mokbel, Kefah; Wazir, Umar; Mokbel, Kinan ANTICANCER RESEARCH 2019, 39 (10): 5231-5259 (September 2019)
Enhancing the potential preclinical and clinical benefits of quercetin through novel drug delivery systems. R Khursheed, SK Singh, S Wadhwa, M Gulatİ - Drug discovery today, 2019. https://doi.org/10.1016/j.drudis.2019.11.001. (August 2019)
Alchemilla vulgaris agg. (Lady's mantle) from central Balkan: antioxidant, anticancer and enzyme inhibition properties. Vlaisavljevic, Sanja; Jelaca, Sanja; Zengin, Gokhan; et al. RSC ADVANCES, 2019, 9(64): 37474-37483. (August 2019)
The Anti-Cancer Effect of Quercetin: Molecular Implications in Cancer Metabolism. Reyes-Farias, Marjorie; Carrasco-Pozo, Catalina. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2019, 20(13): 3177 (July 2019)
Bloom Syndrome Protein Activates AKT and PRAS40 in Prostate Cancer Cells By: Chen, Kun; Xu, Houqiang; Zhao, Jiafu. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY Article Number: 3685817 Published: 2019 (June 2019)
Quercetin shows anti-tumor effect in hepatocellular carcinoma LM3 cells by abrogating JAK2/STAT3 signaling pathway. Wu, L., Li, J., Liu, T., et.al. Cancer Medicine, Volume 8, Issue 10, 2019, Pages 4806-4820 (May 2019)
Traditional Chinese medicine as a cancer treatment: Modern perspectives of ancient but advanced science. By: Xiang, Yuening; Cuo, Zimu; Zhu, Pengfei; et al. CANCER MEDICINE Volume: 8 Issue: 5 Pages: 1958-1975 Published: MAY 2019 (May 2019)
Fisetin and Quercetin: Promising Flavonoids with Chemopreventive Potential By: Kashyap, Dharambir; Garg, Vivek Kumar; Tuli, Hardeep Singh; et al. BIOMOLECULES Volume: 9 Issue: 5 Article Number: 174 Published: MAY 2019 (May 2019)
Midkine silencing enhances the anti–prostate cancer stem cell activity of the flavone apigenin: cooperation on signaling pathways regulated by ERK, p38, PTEN, PARP, and NF-κB. Erdogan, S., Turkekul, K., et.al. Invest New Drugs. 2019 Apr 16. doi: 10.1007/s10637-019-00774-8. (April 2019)
Precision Nutrition and Cancer Relapse Prevention: A Systematic Literature Review Clara Reglero, Guillermo Reglero. Nutrients 2019, 11(11), 2799; https://doi.org/10.3390/nu11112799 (March 2019)
Bakrim, S.; El Omari, N.; El Hachlafi, N.; Bakri, Y.; Lee, L.-H.; Bouyahya, A. Dietary Phenolic Compounds as Anticancer Natural Drugs: Recent Update on Molecular Mechanisms and Clinical Trials. Foods 2022, 11, 3323. https://doi.org/10.3390/foods11213323 (May 2002)

Downregulation of midkine enhances the efficacy of quercetin on androgen-sensitive prostate cancer stem cell survival through arresting cell cycle and inducing apoptosis. Erdogan S, Turkekul K, Serttas, R, Doganlar, Z. B., Doganlar O, Dibirdik I, Bilir A. FEBS OPEN BIO 2018, 8(1): 327 (July 2018)

Investigation of the possible role of luteolin in breast cancer. Erbas H, Kandemir N, Dibirdik I, Aydogdu N, Cakir E. FEBS JOURNAL 283 (SI-S1): 263; 2016 (October 2016)

The flavonoid apigenin reduces prostate cancer CD44(+) stem cell survival and migration through PI3K/Akt/NF-κB signaling. Erdogan S, Doganlar O, Doganlar ZB, Serttas R, Turkekul K, Dibirdik I, Bilir A. Life Sci. 2016, 162:77-86 (August 2016)

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D. Çevik, S. Erdogan, R. Serttas, Y. Kan, H. Kırmızıbekmez, Cytotoxic and Antimigratory Activity of Retrochalcones from Glycyrrhiza echinata L. on Human Cancer Cells. Chem. Biodiversity 2023, 20, e202200589. DOI: 10.1002/cbdv.202200589. (December 2023)
FULGA Ala. ACTIVITATEA BIOCHIMICĂ A EXTRACTELOR DIN SPECIA TARAXACUM OFFICINALE G.H. WEBER ex WIGGERS. 315.01 – BIOCHIMIE MEDICALĂ. Teză de doctor în științe medicale. Chișinău, 2023. Școala doctorală în domeniul Științe medicale. C.Z.U: 615.322:582.998.4:577.1(043.2). (September 2023)
Mehrdad H ve ark. Targeting PI3K/Akt signaling in prostate cancer therapy. Journal of Cell Communication and Signaling 17 (3) 423 – 443) 2023. DOI: 10.1007/s12079-022-00702-1. (September 2023)
M.R. Adedayo, J.K. Akintunde, A. Sani, A. Boligo. Effect of nutriment from monoculture fermentation of Adasonia digitata seeds by Penicillium chrysogenum on haematology and functional endpoints of intra and extrahepatic tissues in rats. Medicine in Microecology, Volume 17, 2023, 100085, ISSN 2590-0978, https://doi.org/10.1016/j.medmic.2023.100085 (September 2023)
Jameel, M.; Fatma, H.; Nadtochii, L.A.; Siddique, H.R. Molecular Insight into Prostate Cancer: Preventive Role of Selective Bioactive Molecules. Life (Basel) 2023, 13, 1976. https://doi.org/10.3390/life13101976 (September 2023)
Reyadh R. Al-Rashidi ve ark. Malignant function of nuclear factor-kappaB axis in prostate cancer: Molecular interactions and regulation by non-coding RNAs. Pharmacological Research, Volume 194, 2023, 106775, ISSN 1043-6618, https://doi.org/10.1016/j.phrs.2023.106775 (August 2023)
Ala F ve ark. CAN DANDELION’S PHENOLIC COMPOUNDS SUPPRESS GLIOBLASTOMA CELLS VIABILITY? Archives of the Balkan Medical Union Volume 58, Issue 1, Pages 8 – 172023. DOI: 10.31688/ABMU.2023.58.1.01 (May 2023)
Ayesha Waheed ve ark. Insights into Pharmacological Potential of Apigenin through Various Pathways on a Nanoplatform in Multitude of Diseases. Current Pharmaceutical Design 29, Issue 17, 2023 [1326 - 1340] DOI: 10.2174/1381612829666230529164321 (April 2023)
Maru, D and Kumar, A. Phytochemicals in the Synthetic Era: A Potential Oncosuppressor against Cancer Stem Cells. Anti-Cancer Agents in Medicinal Chemistry 2023, 23 (11) , pp.1242-1252. DOI: 10.2174/1871520623666230227113239. (April 2023)
Kim, S.; Shin, Y.; Choi, Y.; Lim, K.-M.; Jeong, Y.; Dayem, A.A.; Lee, Y.; An, J.; Song, K.; Jang, S.B.; et al. Improved Wound Healing and Skin Regeneration Ability of 3,2′ -Dihydroxyflavone-Treated Mesenchymal Stem Cell-Derived Extracellular Vesicles. Int. J. Mol. Sci. 2023, 24, 6964. https://doi.org/10.3390/ijms24086964 (April 2023)
Jeong, S.H.; Kim, H.H.; Park, M.Y.; Bhosale, P.B.; Abusaliya, A.; Won, C.K.; Park, K.I.; Kim, E.; Heo, J.D.; Kim, H.W.; et al. Flavones: The Apoptosis in Prostate Cancer of Three Flavones Selected as Therapeutic Candidate Models. Int. J. Mol. Sci. 2023, 24, 9240. https:// doi.org/10.3390/ijms24119240 (April 2023)
Ghanbari-Movahed, M.; Shafiee, S.; Burcher, J.T.; Lagoa, R.; Farzaei, M.H.; Bishayee, A. Anticancer Potential of Apigenin and Isovitexin with Focus on Oncogenic Metabolism in Cancer Stem Cells. Metabolites 2023, 13, 404. https://doi.org/10.3390/metabo13030404 (March 2023)
Y. Zhang, L. Jiang, Y. Jia, Z. Li, Apigenin and its nanoformulations for ameliorating normal tissue toxicity and enhancing tumor response to therapy: A mechanistic viewpoint, Journal of Drug Delivery Science and Technology (2023), doi: https://doi.org/10.1016/j.jddst.2023.105165 (February 2023)
Dicle Çevik, Suat Erdogan, Riza Serttas, Yüksel Kan, and Hasan Kırmızıbekmez. Cytotoxicand AntimigratoryActivityof RetrochalconesfromGlycyrrhizaechinataL. on HumanCancerCells. Chem.Biodiversity2022,19,e202200589. doi.org/10.1002/cbdv.202200589 (October 2022)
Saima Khatoon, Nida Kalam, Vinod RMT Balasubramaniam, Mohd. Farooq Shaikh* and Mohammad Tahir Ansari*. Chemotherapeutic Role of Polyphenols Present in Ocimum sanctum. Anti-Cancer Agents in Medicinal Chemistry. Volume 22, Issue 20, 2022 Published on: 07 September, 2022 Page: [3325 - 3342] DOI: (September 2022)
Ji X, Liu K, Li Q, Shen Q, Han F, Ye Q and Zheng C (2022) A Mini-Review of Flavone Isomers Apigenin and Genistein in Prostate Cancer Treatment. Front. Pharmacol. 13:851589. doi: 10.3389/fphar.2022.851589 (September 2022)
Erdogan, S., Serttas, R., Turkekul, K. et al. The synergistic anticancer effect of salinomycin combined with cabazitaxel in CD44+ prostate cancer cells by downregulating wnt, NF-κB and AKT signaling. Mol Biol Rep 49, 4873–4884 (2022). https://doi.org/10.1007/s11033-022-07343-y (September 2022)
Sharma E, Attri DC, Sati P, Dhyani P, Szopa A, Sharifi-Rad J, Hano C, Calina D and Cho WC (2022) Recent updates on anticancer mechanisms of polyphenols. Front. Cell Dev. Biol. 10:1005910. doi: 10.3389/fcell.2022.1005910 (September 2022)
Schmitt, F.; Eckert, G.P. Caenorhabditis elegans as a Model for the Effects of Phytochemicals on Mitochondria and Aging. Biomolecules 2022, 12, 1550. https://doi.org/10.3390/biom12111550 (September 2022)
Fatih Genc, Ugur Simal Atabey, Riza Serttas and Suat Erdogan*. Abiraterone Acetate, in Combination with Apigenin, Attenuates the Survival of Human Castration-Sensitive Prostate Cancer Cells. Anti-Cancer Agents in Medicinal Chemistry. Volume 22, Issue 18, 2022 Published on: 02 August, 2022 Page: [3148 - 3156] DOI: 10.2174/1871520622666220426095257 (August 2022)
Roohi Mohi-ud-din, Reyaz Hassan Mir, Saba Sabreen, Rafia Jan, Faheem Hyder Pottoo* and Inder Pal Singh*. Recent Insights into Therapeutic Potential of Plant-Derived Flavonoids against Cancer. Anti-Cancer Agents in Medicinal Chemistry. Volume 22, Issue 20, 2022 Published on: 17 August, 2022 Page: [3343 - 3369] DOI: 10.2174/1871520622666220421094055 (August 2022)
Omolola R. Oyenihi, Ayodeji B. Oyenihi, Toyin D. Alabi, Oluwatosin G. Tade, Anne A. Adeyanju, Oluwafemi O. Oguntibeju. Reactive oxygen species: Key players in the anticancer effects of apigenin? Journal of Food Biochemistry Volume 46, Issue 2 e14060. https://doi.org/10.1111/jfbc.14060 (June 2022)
Fakhri S, Moradi SZ, Yarmohammadi A, Narimani F, Wallace CE and Bishayee A (2022) Modulation of TLR/NF-κB/NLRP Signaling by Bioactive Phytocompounds: A Promising Strategy to Augment Cancer Chemotherapy and Immunotherapy. Front. Oncol. 12:834072. doi: 10.3389/fonc.2022.834072 (June 2022)
Leyane, T.S.; Jere, S.W.; Houreld, N.N. Oxidative Stress in Ageing and Chronic Degenerative Pathologies: Molecular Mechanisms Involved in Counteracting Oxidative Stress and Chronic Inflammation. Int. J. Mol. Sci. 2022, 23, 7273. https://doi.org/10.3390/ijms23137273 (June 2022)
Li H, Wang B, Qi B, Jiang G, Qin M and Yu M: Connexin32 regulates expansion of liver cancer stem cells via the PI3K/Akt signaling pathway. Oncol Rep 48: 166, 2022. https://doi.org/10.3892/or.2022.8381 (June 2022)
Sufianova G, Gareev I, Beylerli O, Wu J, Shumadalova A, Sufianov A, Chen X and Zhao S (2022) Modern aspects of the use of natural polyphenols in tumor prevention and therapy. Front. Cell Dev. Biol. 10:1011435. doi: 10.3389/fcell.2022.1011435 (June 2022)
Hashemi, M., Taheriazam, A., Daneii, P. et al. Targeting PI3K/Akt signaling in prostate cancer therapy. J. Cell Commun. Signal. (2022). https://doi.org/10.1007/s12079-022-00702-1 (June 2022)
Yihua Shi, Kai Lian, Jiguang Jia, "Apigenin Suppresses the Warburg Effect and Stem-like Properties in SOSP-9607 Cells by Inactivating the PI3K/Akt/mTOR Signaling Pathway", Evidence-Based Complementary and Alternative Medicine, vol. 2022, Article ID 3983637, 10 pages, 2022. https://doi.org/10.1155/2022/3983637 (May 2022)
Md Sohanur Rahaman, Md Afjalus Siraj, Md Arman Islam, Prayas Chakma Shanto, Ordha Islam, Md Amirul Islam, Jesus Simal-Gandara. Crosstalk between xanthine oxidase (XO) inhibiting and cancer chemotherapeutic properties of comestible flavonoids- a comprehensive update. The Journal of Nutritional Biochemistry, Volume 110, 2022, 109147, https://doi.org/10.1016/j.jnutbio.2022.109147. (April 2022)
Chengcheng Guan, Xintong Zhou, Huayao Li, Xiaoran Ma, Jing Zhuang. NF-κB inhibitors gifted by nature: The anticancer promise of polyphenol compounds, Biomedicine & Pharmacotherapy, Volume 156, 2022, 113951, https://doi.org/10.1016/j.biopha.2022.113951. (March 2022)
Effects of miR-149-3p-mediated PI3K/AKT signaling pathways on proliferation and apoptosis of endothelial cells from hemangioma in children. Gao, Xiaoyun; Wen, Junping; Yang, Yu; et al. International Journal of Clinical and Experimental Medicine 2019, 12(7): 8149-8160 (September 2019)
Reversal of Multidrug Resistance in Cancer by Multi-Functional Flavonoids By: Ye, Qingmei; Liu, Kai; Shen, Qun; et al. FRONTIERS IN ONCOLOGY Volume: 9 Article Number: 487 Published: JUN 12 2019 (June 2019)
Polyphenols and Cancer Immunology. Chapter 5, p. 107-131. R Paduch. Plants that Fight Cancer. Edited by Spyridon E. Kintzios, Maria G. Barberaki. CRC Press Taylor & Francis Group Florida, 2019. (May 2019)
Metal Complexation and Patent Studies of Flavonoid. V Uivarosi, AC Munteanu, A Sharma. pp 39-89. In “Current Aspects of Flavonoids: Their Role in Cancer Treatment”. Edited by Hardeep Singh Tuli. Springer Nature Singapore Pte Ltd. 2019. (May 2019)
The Prognostic Significance of EIF3C Gene during the Tumorigenesis of Prostate Cancer. Hu, Jianxin; Luo, Heng; Xu, Yuangao; et al. CANCER INVESTIGATION 2019, 37( 4-5): 199-208. (May 2019)
Açai (Euterpe oleracea, Mart.), an Amazonian fruit has antitumor effects on prostate cancer cells. ML Jobim, F Barbisan, M Fortuna. Archives in Biosciences & Health, v. 1, n. 1, p. 61-76, 2019. (April 2019)
Açai (Euterpe oleracea, Mart.), an Amazonian fruit has antitumor effects on prostate cancer cells. ML Jobim, F Barbisan, M Fortuna. Archives in Biosciences & Health, v. 1, n. 1, p. 61-76, 2019. (April 2019)
Midkine silencing enhances the anti–prostate cancer stem cell activity of the flavone apigenin: cooperation on signaling pathways regulated by ERK, p38, PTEN, PARP, and NF-κB. Erdogan, S., Turkekul, K., et.al. Invest New Drugs. 2019 Apr 16. doi: 10.1007/s10637-019-00774-8. (April 2019)
Selenium attenuates docetaxel-induced apoptosis and mitochondrial oxidative stress in kidney cells. Bas, Ercan; Naziroglu, Mustafa. ANTI-CANCER DRUGS 2019, 30 (4): 339-346 (April 2019)
Molecular Mechanisms and Bioavailability of Polyphenols in Prostate Cancer. Costea, Teodora; Nagy, Peter; Ganea, Constanta; et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Volume: 20 Issue: 5 Article Number: 1062 Published: MAR 1 2019 (March 2019)
Apigenin as an effective anticancer natural product: Spotlight on TRAIL, WNT/-catenin, JAK-STAT pathways, and microRNAs. Ozbey, Ulku; Attar, Rukset; Azalea Romero, Mirna; et al. JOURNAL OF CELLULAR BIOCHEMISTRY Volume: 120 Issue: 2 Pages: 1060-1067 Published: FEB 2019 (February 2019)
Flavonoids and Cancer Stem Cells Maintenance and Growth. K Kandhari, H Agraval, A Sharma, et al. In: Rani V., Yadav U. (eds) Functional Food and Human Health. Springer, Singapore, 2018. https://doi.org/10.1007/978-981-13-1123-9_26
Apigenin as an effective anticancer natural product: Spotlight on TRAIL, WNT/β‐catenin, JAK‐STAT pathways, and microRNAs. U Ozbey, R Attar, MA Romero, et al. J Cell Biochem. 2018 Oct 2. doi: 10.1002/jcb.27575.
Esculetin Inhibits the Survival of Human Prostate Cancer Cells by Inducing Apoptosis and Arresting the Cell Cycle. K Turkekul, RD Colpan, T Baykul, et al. J Cancer Prev. 2018 Mar;23(1):10-17. doi: 10.15430/JCP.2018.23.1.10.
Downregulation of annexin A3 inhibits tumor metastasis and decreases drug resistance in breast cancer. Du, Ruikai; Liu, Bingjie; Zhou, Lei; et al. CELL DEATH & DISEASE Volume: 9 Article Number: 126 Published: JAN 26 2018
Apigenin: A dietary flavonoid with diverse anticancer properties. Madunic, Josip; Madunic, Ivana Vrhovac; Gajski, Goran; et al. CANCER LETTERS Volume: 413 Pages: 11-22 Published: JAN 28 2018
The miR-203/SNAI2 axis regulates prostate tumor growth, migration, angiogenesis and stemness potentially by modulating GSK-3/-CATENIN signal pathway. Tian, Xinxin; Tao, Fangfang; Zhang, Baotong; et al. IUBMB LIFE Volume: 70 Issue: 3 Pages: 224-236 Published: MAR 2018
Chlorogenic acid regulates apoptosis and stem cell marker-related gene expression in A549 human lung cancer cells. Yamagata, Kazuo; Izawa, Yuri; Onodera, Daiki; et al. MOLECULAR AND CELLULAR BIOCHEMISTRY Volume: 441 Issue: 1-2 Pages: 9-19 Published: APR 2018
Targeting oncogenic transcription factors by polyphenols: A novel approach for cancer therapy. Rajagopal, Chitra; Lankadasari, Manendra Babu; Aranjani, Jesil Mathew; et al. PHARMACOLOGICAL RESEARCH Volume: 130 Pages: 273-291 Published: APR 2018
Role of metabolism in cancer cell radioresistance and radiosensitization methods. Tang, Le; Wei, Fang; Wu, Yingfen; et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH Volume: 37 Article Number: 87 Published: APR 23 2018
The biology and role of CD44 in cancer progression: therapeutic implications. Chen, Chen; Zhao, Shujie; Karnad, Anand; et al. JOURNAL OF HEMATOLOGY & ONCOLOGY Volume: 11 Article Number: 64 Published: MAY 10 2018
Apigenin enhances the antitumor effects of cetuximab in nasopharyngeal carcinoma by inhibiting EGFR signaling. Hu, Wen-Jian; Liu, Jing; Zhong, Lun-Kun; et al. BIOMEDICINE & PHARMACOTHERAPY Volume: 102 Pages: 681-688 Published: JUN 2018
The Flavonoid Apigenin Is a Progesterone Receptor Modulator with In Vivo Activity in the Uterus. Dean, Matthew; Austin, Julia; Jinhong, Ren; et al. HORMONES & CANCER Volume: 9 Issue: 4 Pages: 265-277 Published: AUG 2018
Apigenin: A natural bioactive flavone-type molecule with promising therapeutic function. Kashyap, Dharambir; Sharma, Ajay; Tuli, Hardeep Singh; et al. JOURNAL OF FUNCTIONAL FOODS Volume: 48 Pages: 457-471 Published: SEP 2018
Effect of Cinnamic acid and FOLFOX in diminishing side population and downregulating cancer stem cell markers in colon cancer cell line HT-29. Soltanian, Sara; Riahirad, Helia; Pabarja, Athareh; et al. DARU-JOURNAL OF PHARMACEUTICAL SCIENCES Volume: 26 Issue: 1 Pages: 19-29 Published: SEP 2018
Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases. Tan, Bee Ling; Norhaizan, Mohd Esa; Liew, Winnie-Pui-Pui; et al. FRONTIERS IN PHARMACOLOGY Volume: 9 Article Number: 1162 Published: OCT 16 2018
Midkine downregulation increases the efficacy of quercetin on prostate cancer stem cell survival and migration through PI3K/AKT and MAPK/ERK pathway. Erdogan, Suat; Turkekul, Kader; Dibirdik, Ilker; et al. BIOMEDICINE & PHARMACOTHERAPY Volume: 107 Pages: 793-805 Published: NOV 2018
Naringin sensitizes human prostate cancer cells to paclitaxel therapy. Erdogan, Suat; Doganlar, Oguzhan; Doganlar, Zeynep B.; et al. PROSTATE INTERNATIONAL Volume: 6 Issue: 4 Pages: 126-135 Published: DEC 2018

The flavonoid apigenin reduces survival and migration of CD44+ prostate cancer stem cells. S. Erdogan, O. Doganlar, Z. B. Doganlar, R. Serttas, K. Turkekul, I. Dibirdik, A. Bilir. FEBS JOURNAL 283 (SI-S1): 299; 2016.

Rational design of an immunoconjugate for selective knock-down of leukemia-specific E2A-PBX1 fusion gene expression in human Pre-B leukemia. Uckun FM, Qazi S, Dibirdik I, Myers DE. Integr Biol (Camb). 2013; 5(1):122-32 (May 2013)

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Yang, M., Tang, Y., Zhu, P. et al. The advances of E2A-PBX1 fusion in B-cell acute lymphoblastic Leukaemia. Ann Hematol (2023). https://doi.org/10.1007/s00277-023-05595-7 (December 2023)
Mangla, P.; Vicentini, Q.; Biscans, A. Therapeutic Oligonucleotides: An Outlook on Chemical Strategies to Improve Endosomal Trafficking. Cells 2023, 12, 2253. https://doi.org/10.3390/cells12182253 (September 2023)
Singh PA ve ark. Bonding through phosphodiester moiety: Its implications in pharmaceutical modifications. Pages 245 - 2781 January 2023. In “Polymer-Drug Conjugates: Linker Chemistry, Protocols and Applications“. Elsevier Publishing. ISBN 978-032391663-9, 978-032391690-5. DOI: 10.1016/B978-0-323-91663-9.00009-6 (January 2023)
Super-resolution microscopy reveals ultra-low CD19 expression on myeloma cells that triggers elimination by CD19 CAR-T. Nerreter, Thomas; Letschert, Sebastian; Goetz, Ralph; et al. NATURE COMMUNICATIONS Volume: 10 Article Number: 3137 Published: JUL 17 2019 (July 2019)
Disulfide bridge as a linker in nucleic acids’ bioconjugation. Part II: A summary of practical applications. Bioorganic Chemistry, Volume 95, 2019. https://doi.org/10.1016/j.bioorg.2019.103518 (June 2019)
Antibody-Antisense Oligonucleotide Conjugate Downregulates a Key Gene in Glioblastoma Stem Cells. Arnold, Amy E.; Malek-Adamian, Elise; Le, Phuong U.; et al. MOLECULAR THERAPY-NUCLEIC ACIDS Volume: 11 Pages: 518-527 Published: JUN 1 2018
Oligonucleotide conjugates - Candidates for gene silencing therapeutics By: Gooding, Matt; Malhotra, Meenakshi; Evans, James C.; et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS Volume: 107 Pages: 321-340 Published: OCT 2016 (October 2016)
Novel Targeted Therapy for Precursor B-Cell Acute Lymphoblastic Leukemia: Anti-CD22 Antibody-MXD3 Antisense Oligonucleotide Conjugate By: Satake, Noriko; Duong, Connie; Yoshida, Sakiko; et al. MOLECULAR MEDICINE Volume: 22 Pages: 632-642 Published: 2016

In vitro and in vivo chemosensitizing activity of LFM-A13, a dual-function inhibitor of Bruton’s tyrosine kinase and Polo-like kinases, against human leukemic B-cell precursors. Uckun FM, Dıbırdık I, Sarkissian A and Qazi S. Drug Research/Arzneimittelforschung 2011; 61(4): 252-9.

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CD22 exon 12 deletion as a pathogenic mechanism of human B-precursor leukemia. Uckun FM, Goodman P, Ma H, Dıbırdık I, Qazi S. Proceedings of the National Academy of Sciences (PNAS), 2010; 07(39): 16852-7. (September 2010)

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Zhang, S., Li, P., Li, J. et al. Chromatin accessibility uncovers KRAS-driven FOSL2 promoting pancreatic ductal adenocarcinoma progression through up-regulation of CCL28. Br J Cancer 129, 426–443 (2023). https://doi.org/10.1038/s41416-023-02313-y (August 2023)
Takashi Angata, Ajit Varki. Discovery, classification, evolution and diversity of Siglecs. Molecular Aspects of Medicine, Volume 90, 2023, 101117, ISSN 0098-2997, https://doi.org/10.1016/j.mam.2022.101117 (April 2023)
Qazi, S.; Uckun, F.M. CD22 Exon 12 Deletion as an Independent Predictor of Poor Treatment Outcomes in B-ALL. Cancers 2023, 15, 1599. https://doi.org/10.3390/cancers15051599. (March 2023)
Liu, Y., Wang, Y., Yang, Y. et al. Emerging phagocytosis checkpoints in cancer immunotherapy. Sig Transduct Target Ther 8, 104 (2023). https://doi.org/10.1038/s41392-023-01365-z (March 2023)
Chen, Y., Jiang, P., Lei, S., Chen, X., Yao, S., Jiang, D., Lin, D., Jia, X., Hu, J.,Optical tweezers and Raman spectroscopy for single-cell classification of drug resistance in acute lymphoblastic leukemia. J. Biophotonics 2022, 15( 9), e202200117. https://doi.org/10.1002/jbio.202200117 (October 2022)
Sisi Zheng, Elisabeth Gillespie, Ammar S. Naqvi. Modulation of CD22 Protein Expression in Childhood Leukemia by Pervasive Splicing Aberrations: Implications for CD22-Directed Immunotherapies . Blood Cancer Discov 2022;3:103–15 doi: 10.1158/2643-3230.BCD-21-0087 (August 2022)
Jessie Bourcier; Omar Abdel-Wahab. Splicing-Mediated Antigen Escape from Immunotherapy for B-cell Malignancies. Blood Cancer Discov (2022) 3 (2): 87–89. https://doi.org/10.1158/2643-3230.BCD-21-0200 (June 2022)
Pennesi, E., Michels, N., Brivio, E. et al. Inotuzumab ozogamicin as single agent in pediatric patients with relapsed and refractory acute lymphoblastic leukemia: results from a phase II trial. Leukemia 36, 1516–1524 (2022). https://doi.org/10.1038/s41375-022-01576-3 (June 2022)
Sialylation is involved in cell fate decision during development, reprogramming and cancer progression. Li, Fenjie; Ding, Junjun. PROTEIN & CELL 2019, 10(8): 550-565 (October 2019)
Smart bomb: Potential applications and future perspectives in aquaculture. M Patnaik, PC Nandanpawar, A Khuntia Murmu. International Journal of Fisheries and Aquatic Studies 2018; 6(2): 12-19
Sialylation is involved in cell fate decision during development, reprogramming and cancer progression. F Li, J Ding. Protein & cell, 2018; https://doi.org/10.1007/s13238-018-0597-5
Down-regulation of siglec-2 (CD22) predicts worse overall survival from HBV-related early-stage hepatocellular carcinoma: a preliminary analysis from Gene Expression Omnibus. X Ren, Y Ji, X Jiang, X Qi. Bioscience Reports Nov 28, 2018, 38 (6) BSR20181423; DOI: 10.1042/BSR20181423.
Identification and targeting of CD22ΔE12 as a molecular RNAi target to overcome drug resistance in high-risk B-lineage leukemias and lymphomas. FM Uckun, S Qazi. Cancer Drug Resist 2018;1:30-47; 10.20517/cdr.2017.03.
Possible Influences of Endogenous and Exogenous Ligands on the Evolution of Human Siglecs. Angata, Takashi. FRONTIERS IN IMMUNOLOGY Volume: 9 Article Number: 2885 Published: DEC 4 2018
Screening of Variations in CD22 Gene in Children with B-Precursor Acute Lymphoblastic Leukemia By: Oner, Deniz Aslar; Akin, Dilara Fatma; Sipahi, Kadir; et al. GENETIC TESTING AND MOLECULAR BIOMARKERS Volume: 20 Issue: 9 Pages: 552-555 Published: SEP 2016 (September 2016)

Augmentation of the anti-leukemic potency of total body irradiation (TBI) by a novel P-site inhibitor of spleen tyrosine kinase (SYK). Uckun FM, Dıbırdık I, Qazi S. Radiation Research, 2010; 174(4): 526-31.

Chemoprevention of colorectal cancer by targeting Janus Kinase 3 with a rationally designed small molecule inhibitor. Uckun FM, Dıbırdık I. Nutrition and Cancer, 2010; 62 (7): 968-972.

Prevention of UVB-induced skin inflammation, genotoxicity, and photocarcinogenesis in mice by WHI-P131, a dual-function inhibitor of Janus kinase 3 and EGF-receptor kinase. Uckun FM, Dıbırdık I, Qazi S. Drug Research / Arzneimittelforschung 2010; 60(4): 218-225.

Therapeutic nanoparticle constructs of a JAK3 tyrosine kinase inhibitor against human B lineage ALL cells. Uckun FM, Dıbırdık I, Qazi S, Yiv S. Drug Research/Arzneimittelforschung 2010; 60(4): 210-217.

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Targeting JAK3 tyrosine kinase-linked signal transduction pathways with rationally-designed inhibitors. Uckun FM, Vassilev A, Dıbırdık I, Tibbles H. Anticancer Agents Med. Chem. 2007; 7(6): 612-23. (November 2007)

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Anti-breast cancer activity of LFM-A13, a potent inhibitor of Polo-like kinase (PLK). Uckun FM, Dıbırdık I, Qazi S, Vassilev A, Ma H, Mao C, Benyumov A, Emami KH. Bioorg Med Chem. 2007;15 (2):800-14. (January 2007)

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FM Uckun, T Venkatachalam. Synthetic dimeric cinchona alkaloids against cancer. US Patent 11,649,232 B2. 2023. (May 2023)
Shan-Liang Sun, Shi-Han Wu, Ji-Bo Kang, Yi-Yuan Ma, Lu Chen, Peng Cao, Liang Chang, Ning Ding, Xin Xue, Nian-Guang Li, and Zhi-Hao Shi/ Medicinal Chemistry Strategies for the Development of Bruton’s Tyrosine Kinase Inhibitors against Resistance. Journal of Medicinal Chemistry 2022 65 (11), 7415-7437. DOI: 10.1021/acs.jmedchem.2c00030. (August 2022)
Effects of Tec Tyrosine Kinase Inhibition on the Inflammatory Response of Severe Acute Pancreatitis-Associated Acute Lung Injury in Mice. Meng, Yiteng; Sha, Shuo; Yang, Jing; et al. DIGESTIVE DISEASES AND SCIENCES Volume: 64 Issue: 8 Pages: 2167-2176 Published: AUG 2019 (August 2019)
Type I and III Interferon Productions are Impaired in X-linked Agammaglobulinemia Patients Towards Poliovirus but not Influenza Virus. DWA Luk, K Ni, Y Wu, et al. Frontiers in Immunol, Volume 9 | Article 1826 , 2018; https://doi.org/10.3389/fimmu.2018.01826
Simultaneous use of erythropoietin and LFM-A13 as a new therapeutic approach for colorectal cancer. Tankiewicz-Kwedlo, Anna; Hermanowicz, Justyna Magdalena; Domaniewski, Tomasz; et al. BRITISH JOURNAL OF PHARMACOLOGY Volume: 175 Issue: 5 Pages: 743 762 Published: MAR 2018
Erythropoietin Intensifies the Proapoptotic Activity of LFM-A13 in Cells and in a Mouse Model of Colorectal Cancer. Tankiewicz-Kwedlo, Anna; Hermanowicz, Justyna Magdalena; Pawlak, Krystyna; et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Volume: 19 Issue: 4 Article Number: 1262 Published: APR 2018
LFM-A13, a potent inhibitor of polo-like kinase, inhibits breast carcinogenesis by suppressing proliferation activity and inducing apoptosis in breast tumors of mice. Sahin, Kazim; Tuzcu, Mehmet; Yabas, Mehmet; et al. INVESTIGATIONAL NEW DRUGS Volume: 36 Issue: 3 Pages: 388-395 Published: JUN 2018
NOTCH and Graft-Versus-Host Disease. Di Ianni, Mauro; Del Papa, Beatrice; Baldoni, Stefano; et al. FRONTIERS IN IMMUNOLOGY Volume: 9 Article Number: 1825 Published: AUG 10 2018
PLK-1: Angel or devil for cell cycle progression By: Kumar, Shiv; Sharma, Ashish Ranjan; Sharma, Garima; et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER Volume: 1865 Issue: 2 Pages: 190-203 Published: APR 2016 (April 2016)
Exploration of Novel Inhibitors for Bruton's Tyrosine Kinase by 3D QSAR Modeling and Molecular Dynamics Simulation By: Bavi, Rohit; Kumar, Raj; Choi, Light; et al. PLOS ONE Volume: 11 Issue: 1 Article Number: e0147190 Published: JAN 19 2016 (January 2016)

Anti-cancer activity profile of 3'-azidothymidine 5'-[p-methoxyphenyl methoxyalaninyl phosphate] (Compound 003), a novel nucleoside analog. Uckun FM, Vassilev AO, Dıbırdık I, Liu XP, Erbeck D, Tibbles HE, Qazi S, Venkatachalam TK. Drug Research /Arzneimittelforschung. 2004;54(11):715-31.

In vitro and in vivo pharmacokinetic features and metabolism of the novel cytotoxinucleoside analog 3'-azidothymidine 5'-[p-methoxyphenyl methoxyalaninyl phosphate] (Compound 003). Uckun FM, Chen CL, Liu XP, Dıbırdık I, Venkatachalam TK. Drug Research / Arzneimittelforschung. 2004 ; 54(11): 732-45.

Stimulation of Bruton's Tyrosine kinase (BTK) and inositol 1,4,5-trisphosphate production in leukemia and lymphoma cells exposed to low-energy electromagnetic fields. Dıbırdık I, Bofenkamp M, Skeben P, Uckun FM. Leukemia and Lymphoma 40(1-2):149-156, 2000.

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ATIF

Targeting Janus kinase 3 in mast cells prevents immediate hypersensitivity reactions and anaphylaxis. Malaviya R, Zhu D, Dıbırdık I, Uckun FM. J Biol Chem., 274(38): 27028-38, 1999.

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Kumar, P.; Mishra, J.; Kumar, N. Mechanistic Role of Jak3 in Obesity-Associated Cognitive Impairments. Nutrients 2022, 14, 3715. https://doi.org/10.3390/ nu14183715 (August 2022)
Pyrrole heteroaryl ring derivative and method of use thereof. Xuejun Zhang, Qing Dong, Bonian Liu, Yaoping Zhu, Xiaotao Li, Jiong Lan. US Patent No US10428074B2. 2019-10-01. (October 2019)
Heterocyclic compounds and uses thereof. Kwangho Lee, Deqiang Niu, Russell C. Petter, Matthew Frank Baevsky, Juswinder Singh. US Patent No US10434101B2. 2019-10-08. (October 2019)
Inhibitors of influenza viruses replication. LJ Farmer, MJ Boyd, D Shannon, M Waldo, vb. US Patent No US10273233B2; 2019-04-30. (April 2019)
Forms and compositions of an ERK inhibitor. Antonio Christian FERRETTI, Lianfeng Huang, Ying Li, John Traverse, Jean Xu, et.al. US Patent No US10202364B2. 2019-02-12. (February 2019)
2,4-disubstituted pyrimidines useful as kinase inhibitors. Juswinder Singh, Russell C. Petter, Richland Wayne Tester et. al. US Patent US10010548B2; 2018-07-03.
EGFR inhibitors and methods of treating disorders. Nathanael S. Gray, Pasi Janne, Michael J. Eck, Wenjun Zhou. US Patent US9908884B2; 2018-03-06.
Substituted 2,4-diaminopyrimidines as kinase inhibitors. Singh, Juswinder, Petter, Russell C., Tester, Richland Wayne et al. US Patent 9987276; 06/05/2018.
Heterocyclic compounds and uses thereof. Kwangho Lee, Deqiang Niu, Russell C. Petter, Matthew Frank Baevsky, Juswinder Singh. US Patent US9867824B2; 2018-01-16.
Inhibitors of influenza viruses replication. Paul S. Charifson, Michael P. Clark, Upul K. Bandarage et. al. US patent US9908878B2; 2018-03-06.
Heteroaryl compounds and uses thereof. Lee, Kwangho, Niu, Deqiang, Petter, Russell C., Singh, Juswinder. US Patent 10081606; 09/25/2018.
Mutant-selective EGFR inhibitors and uses thereof. Kwangho Lee, Deqiang Niu, Matthew Frank Baevsky. US patent US9868723B2; 2018-01-16.
Inhibitors of influenza viruses replication. Paul S. Charifson, Michael P. Clark, Upul K. Bandarage et. al. US patent US10039762B2; 2018-08-07.
ERK inhibitors and uses thereof. Nadia Haq, Deqiang Niu, Russell C. Petter, Lixin Qiao, Juswinder Singh, Zhendong Zhu – US Patent US9980964B2; 2018-05-29
The anti-inflammatory effect of topical tofacitinib on immediate and late-phase cutaneous allergic reactions in dogs: a placebo-controlled pilot study. Blubaugh, Amanda; Rissi, Daniel; Elder, Deborah; et al. VETERINARY DERMATOLOGY Volume: 29 Issue: 3 Pages: 250-+ Published: JUN 2018
Mast cell stabilisers By: Zhang, Tao; Finn, Deirdre Frances; Barlow, James William; et al. EUROPEAN JOURNAL OF PHARMACOLOGY Volume: 778 Pages: 158-168 Published: MAY 5 2016 (May 2016)

Stimulation of Src family protein tyrosine kinases as a proximal and mandatory step for Syk kinase-dependent phospholipase C gamma 2 activation in lymphoma-B cells exposed to low energy electromagnetic fields. Dıbırdık I, Kristupaitis D, Kurosaki T, Tuel-Ahlgren L, Chu A, Pond D, Tuong D, Luben R, Uckun FM. J.Biol. Chem., 273(7): 4035-4039,1998.

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TXU (anti-CD7)-pokeweed antiviral protein as a potent inhibitor of human immunodeficiency virus. Uckun FM, Chelstrom LM, Tuel-Ahlgren L, Dıbırdık I, Irvin JD, Langlie MC, Myers DE. Antimicrob. Agents Chemother., 42(2):383-388, 1998.

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Effects of prophylactic intravenous immunoglobulin-G therapy on humoral and cellular immune components and their functions in burned patients. Dıbırdık I, Durak N, Kislaoglu E, Kutluay T, Aytemiz C. Burns, 21(2):130-135, 1995. (March 1995)

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ATIF

Signal-transduction through the CD19 receptor during discrete developmental stages of human B-cell ontogeny. Uckun FM, Burkhardt AL, Jarvis L, Jun X, Stealey B, Dıbırdık I, Myers DE, Tuel Ahlgren L, Bolen JB. J. Biol. Chem., 268(28): 21172-21184, 1993.

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ATIF

Interleukin-3 stimulation enhances tyrosine phosphorylation and proliferative activity of human fetal thymocytes and leukemic T-cell precursors at multiple developmental stages of Bcell ontogeny. Uckun FM, Hanson M, Tuel-Ahlgren L, Dıbırdık I, Chandan-Langlie M, Discher D, Obuz V, Schieven GL, Ledbetter JA. Leukemia and Lymphoma, 6:117-132, 1992.

Interleukin-7 receptor engagement stimulates tyrosine phosphorylation, inositol phospholipid turnover, proliferation, and selective differentiation to the CD4 lineage by human fetal thymocytes. Uckun FM, Tuel-Ahlgren L, Obuz V, Smith R, Dıbırdık I, Hanson M, Langlie MC, Ledbetter JA. Proc. Natl. Acad. Sci. USA, 88:6323-6327, 1991.

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T lenfositlerinin prereplikatif fazında kalsiyum ve kalmodulinin önemi Kutluay T, Dıbırdık I, Kisa U, Karaca L. Turkish Journal of Biochemistry, 15(2): 13-23, 1990.

Engagement of interleukin-7 receptor stimulates tyrosine phosphorylation, phosphoinositide turnover, and clonal proliferation of human T-lineage acute lymphoblastic leukemia cells. Dıbırdık I, Chandan-Langlie M, Ledbetter JA, Tuel-Ahlgren L, Obuz V, Waddick KG, Gajl-Peczalska K, Schieven GL, Uckun FM. Blood, 78(3):564-570, 1991.

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Yasunaga, M. (2023). Development of Next-Generation Antibody Therapeutics Using DDS and Molecular Imaging. In: Rezaei, N. (eds) Handbook of Cancer and Immunology. Springer, Cham. pp 1-31. https://doi.org/10.1007/978-3-030-80962-1_200-1. (March 2023)
Daniela Kuzilková, Cristina Bugarin, Katerina Rejlova, Axel R. Schulz, Henrik E. Mei, Maddalena Paganin',Alessandra Biffi, Andrea Biondi, Tomas Kalina, Giuseppe Gaipa. Either IL-7 activation of JAK-STAT or BEZ inhibition of PI3K-AKT-mTOR pathways dominates the single-cell phosphosignature of ex vivotreated pediatric T-cell acute lymphoblastic leukemia cells. HAEMATOLOGICA Vol. 107 No. 6 (2022): June, 2022 https://doi.org/10.3324/haematol.2021.278796 (June 2022)
Flip the coin: IL-7 and IL-7R in health and disease. Barata, J.T., Durum, S.K., Seddon, B. Nature Immunology, 2019, 20(12), pp. 1584-1593 (October 2019)
Antibody therapeutics and immunoregulation in cancer and autoimmune disease. Yasunaga, M. Semin Cancer Biol. 2019 Jun 7. pii: S1044-579X(18)30187-1. doi: 10.1016/j.semcancer.2019.06.001. (June 2019)
IL-7R is essential for leukemia-initiating cell activity of T-cell acute lymphoblastic leukemia. González-García, S., Mosquera, M., Fuentes, P., et.al. Blood 2019, 134(24), pp. 2171-2182 (April 2019)

Interleukin-7 receptor ligation stimulates tyrosine phosphorylation, inositol phospholipid turnover, and clonal proliferation of human B-cell precursors. Uckun FM, Dıbırdık I, Smith R, Tuel-Ahlgren L, Chandan-Langlie M, Schieven GL, Waddick KG, Hanson M, Ledbetter JA. Proc. Natl. Acad. Sci. USA, 88: 3589-3593, 1991.

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Uckun, F.M., Qazi, S., Ozer, Z., Garner, A.L., Pitt, J., Ma, H. and Janda, K.D. (2011), Inducing apoptosis in chemotherapy-resistant B-lineage acute lymphoblastic leukaemia cells by targeting HSPA5, a master regulator of the anti-apoptotic unfolded protein response signalling network. British Journal of Haematology, 153: 741-752. https://doi.org/10.1111/j.1365-2141.2011.08671.x (June 2021)
Apoptosis-inducing vanadium complexes. Narla, R.K., Dong, Y., Ghosh, P., Thoen, K., Uckun, F.M. Drugs of the Future v. 25, n. 10 (2000) : 1053. DOI: 10.1358/dof.2000.025.10.858697 (April 2020)
Fatih M Uckun, Jason Pitt & Sanjive Qazi (2011) JAK3 pathway is constitutively active in B-lineage acute lymphoblastic leukemia, Expert Review of Anticancer Therapy, 11:1, 37-48, DOI: 10.1586/era.10.203 (January 2014)
Qazi, S. and Uckun, F.M. (2010), Gene expression profiles of infant acute lymphoblastic leukaemia and its prognostically distinct subsets. British Journal of Haematology, 149: 865-873. https://doi.org/10.1111/j.1365-2141.2010.08177.x (May 2010)
A validated assay to measure soluble IL-7 receptor shows minimal impact of IL-7 treatment. Caroline Janot-Sardet et.al. Journal of Immunological Methods 353 (2010) 115–123. doi:10.1016/j.jim.2009.12.00 (December 2009)
FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome–positive acute lymphocytic leukemia Paolo Neviani, et.al. J Clin Invest. 2007;117(9):2408-2421. https://doi.org/10.1172/JCI31095. (September 2007)
Boris Bartholdy, Patrick Matthias. Transcriptional control of B cell development and function. Gene, Volume 327, Issue 1, 2004, Pages 1-23, https://doi.org/10.1016/j.gene.2003.11.008. (November 2003)
Larry Cosenza, Gullu Gorgun, Alexander Urbano, Francine Foss. Interleukin-7 receptor expression and activation in nonhaematopoietic neoplastic cell lines. Cellular Signalling. Volume 14, Issue 4, 2002, Pages 317-325, https://doi.org/10.1016/S0898-6568(01)00245-5. (August 2002)
Heather E Fleming, Christopher J Paige. Cooperation between IL-7 and the pre-B cell receptor: a key to B cell selection. Seminars in Immunology. Volume 14, Issue 6, 2002, Pages 423-430, https://doi.org/10.1016/S1044532302000775. (March 2002)
Heather Tibbles, Alexei Vassilev & Fatih M. Uckun (2002) A Dual Function Anti-leukemic Agent with Anti-thrombotic Activity, Leukemia & Lymphoma, 43:5, 1121-1127, DOI: 10.1080/10428190290021650 (January 2002)
Alexander Korte, et.al. EXPRESSION ANALYSIS AND CHARACTERIZATION OF ALTERNATIVELY SPLICED TRANSCRIPTS OF HUMAN IL-7Rα CHAIN ENCODING TWO TRUNCATED RECEPTOR PROTEINS IN RELAPSED CHILDHOOD ALL. Cytokine. Volume 12, Issue 11, 2000, Pages 1597-1608, https://doi.org/10.1006/cyto.2000.0777 (November 2000)
Bis(4,7-dimethyl-1,10-phenanthroline) Sulfatooxovanadium(IV) as a Novel Apoptosis-inducing Anticancer Agent. Rama Krishna Narla el.al. Clin Cancer Res (2000) 6 (4): 1546–1556. (April 2000)
Ilker Dibirdik, Mike Bofenkamp, Peter Skeben & Fatih Uckun (2000) Stimulation of Bruton's Tyrosine Kinase (BTK) and Inositol 1,4,5-Trisphosphate Production in Leukemia and Lymphoma Cells Exposed to Low Energy Electromagnetic Fields, Leukemia & Lymphoma, 40:1-2, 149-156, DOI: 10.3109/10428190009054892 (April 2000)
Yanhong Dong, Rama Krishna Narla, Elise Sudbeck, Fatih M Uckun. Synthesis, X-ray structure, and anti-leukemic activity of oxovanadium(IV) complexes. Journal of Inorganic Biochemistry. Volume 78, Issue 4, 2000, Pages 321-330, https://doi.org/10.1016/S0162-0134(00)00060-X. (February 2000)
R. Hofmeister, A.R. Khaled, N. Benbernou, E. Rajnavolgyi, K. Muegge, S.K. Durum. Interleukin-7: physiological roles and mechanisms of action. Cytokine & Growth Factor Reviews. Volume 10, Issue 1, 1999, Pages 41-60. https://doi.org/10.1016/S1359-6101(98)00025-2. (September 1999)
Ravi Malaviya, DeMin Zhu, Ilker Dibirdik, Fatih M. Uckun. Targeting Janus Kinase 3 in Mast Cells Prevents Immediate Hypersensitivity Reactions and Anaphylaxis. Journal of Biological Chemistry, Volume 274, Issue 38, 1999, Pages 27028-27038, https://doi.org/10.1074/jbc.274.38.27028. (June 1999)
Appasamy PM. Biological and clinical implications of interleukin-7 and lymphopoiesis. Cytokines, Cellular & Molecular Therapy. 1999 Mar;5(1):25-39. PMID: 10390077. (February 1999)
E. B. Sweeney, F. M. Foss, J. R. Murphy, and J. C. vanderSpek. Interleukin 7 (IL-7) Receptor-Specific Cell Killing by DAB389 IL-7: A Novel Agent for the Elimination of IL-7 Receptor Positive Cells. Bioconjugate Chem. 1998, 9, 2, 201–207. https://doi.org/10.1021/bc9701757 (February 1998)
Daiva Kristupaitis, Ilker Dibirdik, Alexei Vassilev, Sandeep Mahajan, Tomohiro Kurosaki, Alice Chu, Lisa Tuel-Ahlgren, Dong Tuong, David Pond, Richard Luben, Fatih M. Uckun. Electromagnetic Field-induced Stimulation of Bruton's Tyrosine Kinase. Journal of Biological Chemistry. Volume 273, Issue 20, 1998, Pages 12397-12401, https://doi.org/10.1074/jbc.273.20.12397. (February 1998)

Stimulation of protein tyrosine phosphorylation, phosphoinositide turnover, and multiple previously unidentified serine/threonine-specific protein kinases by the Pan-B-cell receptor CD40/Bp50 at discrete developmental stages of human B-cell ontogeny. Uckun FM, Schieven GL, Dıbırdık I, Chandan-Langlie M, Tuel-Ahlgren L, Ledbetter J. J. Biol. Chem., 266(2): 17478-17485, 1991.

Yanık hastalarında hümoral immune sistem komponentleri ve B hücre fonksiyonları. Dıbırdık I, Durak N, Kisa U, Kilinc C, Bingöl NK, Karayilanoglu T, Erbil K, Kutluay T, Aytemiz C, Karaca L. Turkish Journal of Biochemistry, 1: 79-89, 1993.

Expression and function of low molecular weight B-cell growth factor receptors on B-cell precursor acute lymphoblastic leukemia cells. Dıbırdık I, Uckun FM, Kutluay T, Karaca L. Turkish Journalof Biochemistry, 18(1): 69-78, 1993.

Early B-cell precursors express functional receptors for human interleukin-7: Ligation of human interleukin-7 receptors with recombinant human interleukin- 7 results in an increased proliferation index. Dıbırdık I, Bingol NK, Kilinc C, Dibirdik LJ, Kurt I, Kutluay T, Karaca L, Uckun FM. Doga-Tr.J.of Medical Sciences, 18:103-113, 1993.

Engagement of the CD19 receptor on human B-lineage leukemia cells activates LCK tyrosine kinase and facilitates radiation-induced apoptosis. Waddick KG, Chae HP, Tuel-Ahlgren L, Jarvis LJ, Dıbırdık I, Myers DE, Uckun FM. Radiat. Res., 136: 313-319, 1993.

Tyrosine phosphorylation is a mandatory proximal step in radiation-induced activation of the protein kinase C signalling pathway in human B-lymphocyte precursors. Uckun FM, Schieven GL, Tuel-Ahlgren L, Dıbırdık I, Myers DE, Ledbetter JA, Song CW. Proc. Natl. Acad. Sci. USA, 90: 252-256, 1993.

Increased urinary hydroxyproline / creatinine and calcium / creatinine ratios in oophorectomized women. Kilinc C, Dıbırdık I, Yilmaz K, Kutluay T, Karaca L. Doga-Tr. J. of Medical Sciences, 17: 177-183, 1993.

The ligation of interleukin-7 receptors on human B-cell precursors by recombinant interleukin-7 results in clonal proliferation by increasing the intracellular calcium concentration. Dıbırdık I, Kilinc C, Bingol NK, Dibirdik LJ, Kurt I, Kutluay T, Karaca L, Uckun FM. Doga- Tr.J.of Medical Sciences, 18:91-101, 1993.

The development and validation of a competitive, microtiter plate enzymeimmunoassay for human albumine in urine. Akman A, Kurt I, Gultepe M, Dıbırdık I, Kilinc C, Kutluay T, Karaca L, Bingol NK. Journal of Immunoassay and Immunochemistry, 16(3): 279-296, 1995.

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Effect of force-feeding on fatty liver production and some blood parameters of native and Romanov geese. Muglalli OH, Ergun A, Dogan S, Dıbırdık I, Nazaroğlu NK, Güler A, Oba G. Tr.J.of Veterinary and Animal Sciences, 21:107-113, 1997.

Electromagnetic field-induced stimulation of Bruton's tyrosine kinase. Kristupaitis D, Dıbırdık I, Vassilev A, Mahajan S, Kurosaki T, Chu A, Tuel-Ahlgren L, Tuong D, Pond D, Luben R, Uckun FM. J Biol Chem., 273(20):12397-401, 1998.

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International Articles

Factors Affecting Mortality in Patients with Acute Pancreatitis and Serum Calcipressin-1 (RCAN-1) Levels. Savaş E, Sayhan MB, Salt O, Dibirdik I (2022). Int J Crit Care Emerg Med 8:150. doi.org/10.23937/2474-3674/1510150 (November 2022)

Levels of serum platelet-derived growth factor-β (PDGF-β) and factors affecting mortality in patients with acute myocardial infarction. Ozbilen MS, Sayhan MB, Salt O, Dibirdik I. Medicine Science 2022;11(3):1098-104. doi: 10.5455/medscience.2022.02.047. (July 2022)

A Novel Diagnostic Marker in Pulmonary Thromboembolism? Platelet-Derived Growth Factor –β. Sakçi D., Sayhan M.B., Salt Ö., Dibirdik İ. Dicle Med J (2022) 49 (1) : 1-11. DOI: 10.5798/dicletip.1085918. (March 2022)

Preclinical and First-In-Human Phase I Clinical Evaluation of Stampidine, a Potent Anti-HIV. Cahn P, Rolon MJ, Gun AM, Ferrari I, Dibirdik I, Qazi S, D'Cruz O, Sahin K, Uckun F. Journal of AIDS & Clinical Research 3: 138.doi:10.4172/2155-6113.1000138; 2012 (January 2012)

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Izabela Siekierska, Dr. Maciej Lukaszewicz, Dr. Remigiusz Worch, Prof. Marzena Jankowska-Anyszka, Dr. Karolina Piecyk. Application of Phosphoramidate ProTide Technology for the Synthesis of 5’-mRNA Cap Analogs Modified on the Exocyclic Amine Group. ChemMedChem 2023, 18, e202200490. ISSN 18607179. DOI: 10.1002/cmdc.202200490 (January 2023)
Target Molecules and Delivery Vehicles for Anti-HIV Drugs In vitro and In vivo. A Bolhassani - Current pharmaceutical design, Current Pharmaceutical Design, Volume 24, Number 29, August 2018, pp. 3393-3401(9). https://doi.org/10.2174/1381612824666180608124549
Phosphoramidates and phosphonamidates (ProTides) with antiviral activity M Slusarczyk, M Serpi, Pertusati, F. (2018). Antiviral Chemistry and Chemotherapy. https://doi.org/10.1177/2040206618775243
Synthesis and biological evaluation of 6-substituted-5-fluorouridine ProTides. M Slusarczyk, S Ferla, A Brancale, et al. Bioorganic & Medicinal Chemistry Volume 26, Issue 3, 1 February 2018, Pages 551-565; https://doi.org/10.1016/j.bmc.2017.11.037.
Symmetrical Diamidates as a Class of Phosphate Prodrugs to Deliver the 5′‐Monophosphate Forms of Anticancer Nucleoside Analogues. M Slusarczyk, V Ferrari, M Serpi, B Gönczy et al. Volume13, Issue21 November 6, 2018, Pages 2305-2316; https://doi.org/10.1002/cmdc.201800504
Current insights into anti-HIV drug discovery and development: a review of recent patent literature (2014–2017). X Zuo, Z Huo, D Kang, G Wu, Z Zhou et al. Expert Opinion on Therapeutic Patents, 28:4, 299-316, DOI: 10.1080/13543776.2018.1438410

In vivo anti-cancer activity of a liposomal nanoparticle construct of multifunctional tyrosine kinase inhibitor 4-(4’-hydroxyphenyl)-amino-6, 7-dimethoxyquinazoline. Dıbırdık I, Yiv S, Qazi S, Uckun FM. J Nanomedic Nanotechnol 2010; 1 (1): 001-004.

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ATIF

Demir eksikligi anemili hasta lenfositlerinde fitohemaglutinine yanit. Kutluay T, Dıbırdık I, Kısa U, Karaca L. Turkish Journal of Biochemistry, 15(2): 25-32, 1990.

Alpha-tocopherol and gingko biloba treatment protects lipid peroxidation during ischemic period in rat groin island skin flaps. Deveci M, Dıbırdık I, Celiköz B, Selmanpakoglu N, Kisa U. Eur. J. Plastic Surgery, 20:141-144,1997.

International Conference Proceedings

Kurkuminin Diyetsel Karnitin Kaynaklı TMAO ile Değiştirilmiş Kardiyovasküler Parametreler Üzerindeki Etkisi / INSAC International Researches Congress on Health and Life Sciences (INSAC-IRHES'23) (March 2023)

OZER BO, DIBIRDIK I. A NON-SELECTIVE Β-ADRENOCEPTOR ANTAGONIST, PROPRANOLOL, SUPPRESSES THE PROLIFERATION OF HT-29 HUMAN COLORECTAL ADENOCARCINOMA CELLS IN VITRO. Pg 345-349. 6th International Congress on Medical Sciences and Multidisciplinary Approaches. 11-12 Mart 2023 İstanbul. ISBN 978-625-7367-90-5. (March 2023)

OZER BO, DIBIRDIK I. DESIGN, EXPERIMENTATION AND COMPUTERIZED AUTOMATED DATA ANALYSIS OF DRUG COMBINATIONS AGAINST HT-29 HUMAN COLORECTAL CANCER CELLS BY GALLIC ACID AND CETUXIMAB. Pg 339-344. 6th International Congress on Medical Sciences and Multidisciplinary Approaches. 11-12 Mart 2023 İstanbul. ISBN 978-625-7367-90-5. (March 2023)

Cetuximab and ABS interacts synergistically for the inhibition of HT-29 colorectal cancer cell line proliferation (November 2018)

Combination of ABS and Cisplatin has Potent and Synergistic Activity Against MCF-7 Human Breast Cancer Cells. Cigdem FIDAN, Busra DILER ZENGINER, Ilker DIBIRDIK Union of Thrace Universities 2nd International Health Sciences Congress. 15-17 November 2018, Tekirdağ, Turkey. (November 2018)

International Conferences and Symposiums

Is beta-adrenoceptor antagonist nadolol cytotoxic to HT-29 human colorectal adenocarcinoma cells? BO Özer, İ Dıbırdık. 5th International Eurasian Conference on Biological and Chemical Sciences (EurasianBioChem 2022) November 23-25, 2022 (November 2022)

Effects of sulfisomidine, a sulfonamide derivative, on HT-29 human colorectal cancer cell line in vitro. BO Özer, İ Dıbırdık. 5th International Eurasian Conference on Biological and Chemical Sciences (EurasianBioChem 2022) November 23-25, 2022 (November 2022)

Gallic Acid and 5-Fluorouracil Synergistically Inhibit the Proliferation of HT-29 Human Colorectal Cancer Cells In vitro: Analysis of Drug Combinations Using Chou-Talalay Method. BO Özer, İ Dıbırdık. 11th International Molecular Biology and Biotechnology Congress. (October 2022)

Gallic acid, a natural polyphenolic acid, inhibits the growth of HT-29 human colon adenocarcinoma cells in vitro. ÖZER BO, DIBIRDIK İ. 2nd International Conference on “Veterinary Biochemistry and Clinical Biochemistry. OCTOBER 24-26, 2019 ANKARA / TURKEY. P-3; pg 51. (October 2019)

National Articles

Vanillin: is it just an aromatic or a cure for cancer? Mutlu AU, Kanev M, Zenginer BD, Dıbırdık İ. Turkish Med Stud J. 2019;6(3):85-9. (October 2019)

Yanık hastalarında hücresel immune sistemö lenfosit fenotipiö blastik yetenek ve alloreaktivite. Dıbırdık I, Durak N, Kisa U, Yilmaz K, Aytemiz C, Karaca L. Optimal Tıp Dergisi 6(3): 107-111, 1993.

Experimental evaluation of the efficiency of hyperfractioned total body irradiation as a conditioning regimen for bone marrow transplantation. Beyzadeoglu M, Elci H, Pak Y, Pak I, Dirican B, Dıbırdık I. Turkish J. Cancer, 25(2): 65-73 1995.

National Books and Book Chapters

Principles of Biochemistry. 8th Edition. David L. Nelson , Michael M. Cox.

Master`s Theses Advised

Tuğçe Buket ÖZDEMİR (2. Danışman) Enflamatuar bağırsak hastalığı tedavisi için semisentetik fitokimyasal yapı geliştirilmesi. (February 2023)

Mehmet Akıncı (Mezbaha atiklarinin akciğer dokularindan kimyasal ve enzimatik yöntemlerle protein hidrolizat üretimi)

Elif Ecem FINDIK (2. Danışman) (İnflamatuar bağirsak hastaliği tedavisinde biyomolekül bazli terapötik uygulamalar)

Tansu OKTAY (December 2021)
SEZEN ÇOLAKOĞULLARI
Nihayet KANDEMİR

Referee Positions

T.C. Üniversitelerarası Kurul Başkanlığı Doçentlik Atama Jüri Üyeliği (E.Ö.) 2023 Ekim (December 2023)

T.C. Üniversitelerarası Kurul Başkanlığı Doçentlik Atama Jüri Üyeliği (D.İ.T.) 2023 Mart Dönemi (May 2023)

Balkan Medical Journal. Manuscript No: BalkanMedJ-2019-9-91 (December 2019)
TUBAP 2017/217 Sonuç raporu (November 2019)
TUBAP 2018/197 - 3. ara rapor (October 2019)
TUBAP 7415 (September 2019)
TUBAP 2017/217 3. Ara Rapor (June 2019)
Balkan Medical Journal. Manuscript No: BalkanMedJ-2019-3-26 (May 2019)
Balkan Medical Journal. Manuscript No: BalkanMedJ-2019-1-64 (April 2019)
TUBAP 2018/197 - 2. ara rapor (February 2019)
TUBİTAK 1512 #2150139 (GR, SR)
TUBİTAK 1001 #217S571
TUBİTAK 1001 #217S833
TUBİTAK 1001 #217S518
TUBİTAK 1005 #217S380
TUBİTAK 2515 COST - 216S085
TUBİTAK 1001 #218S558
TUBİTAK 1001 #218S514
TUBİTAK 1001 #218S710
TUBİTAK 1001 #218S554
TÜBAP-2016/42 (2.GR, SR)
TÜBAP-2018/197
TÜBAP-2017/71 (SR)
TÜBAP-2017-123 (2.GR)
TÜBAP-2017-217 (2.GR)
TUBİTAK 1005 #217S380

Projects

Obesite ile kanser kök hücre arasındaki ilişkinin prostat kanseri in vitro modelinde analizi (2020/101) (August 2022)

Kurkuminin Diyetsel Karnitin Kaynaklı TMAO ile Değiştirilmiş Kardiyovasküler Parametreler Üzerindeki Etkisi (TÜBAP #2018/369) (December 2018)

» Educational Qualifications

Bachelor`s Degree » Graduated in 1982

Master`s Degree » Graduated in 1988

Doctoral Degree » Graduated in 1992

» Academic Titles

Assistant Professor » In 1996

» Publications

SCI-SSCI or SCI Expanded Articles

International Articles

International Conference Proceedings

International Conferences and Symposiums

National Articles

National Books and Book Chapters

Master`s Theses Advised

Referee Positions

Projects