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AFŞAR, OLKAN and OLTULU, ÇAĞATAY (2023) "Evaluation of the cytotoxic effect of titanium dioxide nanoparticles in human embryonic lung cells," Turkish Journal of Medical Sciences: Vol. 53: No. 6, Article 13. https://doi.org/10.55730/1300-0144.5733 (sci-e Q3) (December 2023)

Ergin, A. D., Üner, B., Balcı, Ş., Demirbağ, Ç., Benetti, C., & Oltulu, Ç. (2023). Improving the Bioavailability and Efficacy of Coenzyme Q10 on Alzheimer's Disease Through the Arginine Based Proniosomes. Journal of pharmaceutical sciences, 112(11), 2921–2932. https://doi.org/10.1016/j.xphs.2023.07.020 (sci-e Q2) (November 2023)

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Ergin, A. D., Oltulu, Ç., Türker, N. P., & Demirbolat, G. M. (2023). In vitro hepatotoxicity evaluation of methotrexate-loaded niosome formulation: fabrication, characterization and cell culture studies. Turkish journal of medical sciences, 53(4), 872–882. https://doi.org/10.55730/1300-0144.5651 (sci-e Q3) (August 2023)

Ergin, A. D., Oltulu, Ç., & Koç, B. (2023). Enhanced Cytotoxic Activity of 6-Mercaptopurine–Loaded Solid Lipid Nanoparticles in Hepatic Cancer Treatment. ASSAY and Drug Development Technologies, 21(5), 212-221. http://doi.org/10.1089/adt.2023.007 (sci-e Q4) (June 2023)

Çağatay Oltulu, Melek Akıncı, Elvan Bakar. Evaluation of the cytotoxic effect of the combination of carboplatin and carvacrol. "Oral Presentation Abstracts" Turkish Journal of Biochemistry, vol. 46, no. s1, 2021, pp. 43-70. https://doi.org/10.1515/tjb-2021-46s107 (November 2021)

Melek Akinci, Cetin Hakan Karadag, Serhat Huseyin, Cagatay Oltulu, Suat Canbaz, Ozgur Gunduz, Ruhan Deniz Topuz. Effects of in vitro Amitriptyline, Fluoxetine, Tranylcypromine and Venlafaxine on Saphenous Vein Grafts. Braz J Cardiovasc Surg. 2019;34(3):290-296. https://doi.org/10.21470/1678-9741-2018-0338 (sci-e Q4) (June 2019)

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OLTULU C., KARADAG CH.. The Effect of Intrauterine Antipsychotic Drug Exposure on Learning and Memory in Adult Rats. Bulletin of Clinical Psychopharmacology 2016;26(4):364-73 https://doi.org/10.5455/bcp.20160627090254 (sci-e Q4) (December 2016)

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Ulugol A, Oltulu C, Gunduz O, Citak C, Carrara R, Shaqaqi, Sanchez, Dogrul A. 5-HT7 receptor activation attenuates thermal hyperalgesia in streptozocin-induced diabetic mice Pharmacology, Biochemistry and Behaviour 2012; 102(2): 344-348 (August 2012)

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Bardoni, R. (2023). Serotonergic 5-HT7 Receptors as Modulators of the Nociceptive System. Current Neuropharmacology, 21(7), 1548-1557. DOI: https://doi.org/10.2174/1570159X21666221129101800 (SCI) (July 2023)
Saab, M., Raafat, K., & El-Maradny, H. capsaicin nanoemulgel: Optimization, skin permeation and in-vivo activity against diabetic neuropathy. Advanced Pharmaceutical Bulletin, doi: 10.34172/apb. 2022.080.
Saab, M., Raafat, K., & El-Maradny, H. (2021). Transdermal Delivery of Capsaicin Nanoemulgel: Optimization, SkinPermeation and In Vivo Activity against Diabetic Neuropathy. Advanced Pharmaceutical Bulletin, 12(4), 780-790.
Raafat, K., Aboul-Ela, M., & El-Lakany, A. (2021). Alloxan-induced diabetic thermal hyperalgesia, prophylaxis and phytotherapeutic effects of Rheum ribes L. in mouse model. Archives of pharmacal research, 44, 1-10.
SAAB, May; RAAFAT, Karim; EL-MARADNY, Hoda. capsaicin nanoemulgel: Optimization, skin permeation and in-vivo activity against diabetic neuropathy. Advanced Pharmaceutical Bulletin, doi: 10.34172/apb. 2022.080.
BARNES, Nicholas M., et al. International Union of Basic and Clinical Pharmacology. CX. Classification of receptors for 5-hydroxytryptamine; pharmacology and function. Pharmacological reviews, 2021, 73.1: 310-520.
RAAFAT, Karim; ABOUL-ELA, Maha; EL-LAKANY, Abdalla. Alloxan-induced diabetic thermal hyperalgesia, prophylaxis and phytotherapeutic effects of Rheum ribes L. in mouse model. Archives of pharmacal research, 2021, 44.8: 1-10.
Khaleghzadeh-Ahangar, H., Sadeghimahalli, F., Khandan, S., Shahabi, S., & Moghadamnia, A. (2020). Insulin within the Arcuate Nucleus Has Paradoxical Effects on Nociception in Healthy and Diabetic Rats. Basic and Clinical Neuroscience, 11(6), 727.
Shinouchi, R., Shibata, K., Hashimoto, T., Jono, S., Hasumi, K., & Nobe, K. (2020). SMTP‐44D improves diabetic neuropathy symptoms in mice through its antioxidant and anti‐inflammatory activities. Pharmacology Research & Perspectives, 8(6), e00648.
Acklin, S., Zhang, M., Du, W., Zhao, X., Plotkin, M., Chang, J., ... & Xia, F. (2020). Depletion of senescent-like neuronal cells alleviates cisplatin-induced peripheral neuropathy in mice. Scientific reports, 10(1), 14170.
Calcutt, N. A. (2020). Diabetic neuropathy and neuropathic pain: a (con) fusion of pathogenic mechanisms?. Pain, 161(Suppl 1), S65.
Sari, C. C., Gunduz, O., & Ulugol, A. (2019). Spinal serotonin and 5HT6 receptor levels during development of neuropathy and influence of blockade of these receptors on thermal hyperalgesia in diabetic mice. Drug Research, 69(08), 428-433.
Cerles, O., Gonçalves, T. C., Chouzenoux, S., Benoit, E., Schmitt, A., Bennett Saidu, N. E., ... & Batteux, F. (2019). Preventive action of benztropine on platinum-induced peripheral neuropathies and tumor growth. Acta Neuropathologica Communications, 7, 1-23.
Blattner, K. M. (2018). Design, synthesis and evaluation of 5-HT7 antagonists for the treatment of Inflammatory Bowel Disease (Doctoral dissertation, Temple University. Libraries).
MIN, J. C. S. (2018). ANTI-ALLODYNIC AND ANTIHYPERALGESIC EFFECTS OF ZERUMBONE THROUGH INVOLVEMENT OF MONOAMINERGIC PATHWAYS IN MICE MODEL OF NEUROPATHIC PAIN.
Blattner, K. M., Canney, D. J., Pippin, D. A., & Blass, B. E. (2018). Pharmacology and therapeutic potential of the 5-HT7 receptor. ACS Chemical Neuroscience, 10(1), 89-119.
Taciak, P. P., Lysenko, N., & Mazurek, A. P. (2018). Drugs which influence serotonin transporter and serotonergic receptors: pharmacological and clinical properties in the treatment of depression. Pharmacological Reports, 70(1), 37-46.
Jouha, J. (2017). Conception, synthèse et évaluation biologique de nouveaux ligands sérotoninergiques 5-HT₇ (Doctoral dissertation, Université d'Orléans; Université Sultan Moulay Slimane (Beni Mellal, Maroc)).
Raafat, K., & El-Lakany, A. (2017). Combination of Rheum ribes and metformin against diabetes, thermal hyperalgesia, and tactile allodynia in a mice model. Altern Ther Health Med, 23(7), 138-48.
Raafat, K., & Hdaib, F. (2017). Neuroprotective effects of Moringa oleifera: Bio-guided GC-MS identification of active compounds in diabetic neuropathic pain model. Chinese journal of integrative medicine, 1-10.
Sałat, K., Kołaczkowski, M., Furgała, A., Rojek, A., Śniecikowska, J., Varney, M. A., & Newman-Tancredi, A. (2017). Antinociceptive, antiallodynic and antihyperalgesic effects of the 5-HT1A receptor selective agonist, NLX-112 in mouse models of pain. Neuropharmacology, 125, 181-188.
Al-Haj, M. F. (2016). Study of the potential role of Saponaria officinalis L. in diabetic cystopathy and neuropathy in experimental animals.
Su, C., Hu, R., Gu, Y., Han, R., Yan, X., Liao, Q., & Huang, D. (2016). The Nuclear Molecular Imaging of Protein Brain Receptors in Chronic Pain. Current Protein and Peptide Science, 17(6), 559-569.
Raafat, K. M., & Omar, A. G. (2016). Phytotherapeutic activity of curcumol: Isolation, GC–MS identification, and assessing potentials against acute and subchronic hyperglycemia, tactile allodynia, and hyperalgesia. Pharmaceutical Biology, 54(8), 1334-1344.
Raafat, K., Wurglics, M., & Schubert-Zsilavecz, M. (2016). Prunella vulgaris L. active components and their hypoglycemic and antinociceptive effects in alloxan-induced diabetic mice. Biomedicine & pharmacotherapy, 84, 1008-1018.
Üçel, U. İ. (2015). Mianserin'In Streptozotosin Ile Diyabet Oluşturulmuş Sıçanlarda Gelişen Nöropatik Ağrı Üzerine Etkisinin Araştırılması (Doctoral dissertation, Anadolu University (Turkey)).
Reis, V. M. S. (2015). Resposta biológica à implantação subcutânea de nanopartículas de hidroxiapatite em ratos diabéticos (Doctoral dissertation, Universidade de Tras-os-Montes e Alto Douro (Portugal)).
Topuz, R. D., Gunduz, O., & Ulugol, A. (2015). 5-HT7 receptor activation: A novel target for treatment of opioid-induced hyperalgesia–A hypothesis and mini review. neurology, psychiatry and brain research, 21(3), 105-107.
Lin, H., Heo, B. H., Kim, W. M., Kim, Y. C., & Yoon, M. H. (2015). Antiallodynic effect of tianeptine via modulation of the 5-HT7 receptor of GABAergic interneurons in the spinal cord of neuropathic rats. Neuroscience Letters, 598, 91-95.
Micov, A., Tomić, M., Pecikoza, U., Ugrešić, N., & Stepanović-Petrović, R. (2015). Levetiracetam synergises with common analgesics in producing antinociception in a mouse model of painful diabetic neuropathy. Pharmacological Research, 97, 131-142.
Yesilyurt, O., Seyrek, M., Tasdemir, S., Kahraman, S., Deveci, M. S., Karakus, E., ... & Dogrul, A. (2015). The critical role of spinal 5-HT7 receptors in opioid and non-opioid type stress-induced analgesia. European journal of pharmacology, 762, 402-410.
Panczyk, K., Golda, S., Waszkielewicz, A., Zelaszczyk, D., Gunia-Krzyzak, A., & Marona, H. (2015). Serotonergic system and its role in epilepsy and neuropathic pain treatment: a review based on receptor ligands. Current Pharmaceutical Design, 21(13), 1723-1740.
Raafat, K., & El-Lakany, A. (2015). Acute and subchronic in-vivo effects of Ferula hermonis L. and Sambucus nigra L. and their potential active isolates in a diabetic mouse model of neuropathic pain. BMC Complementary and Alternative Medicine, 15, 1-14.
Nikiforuk, A. (2015). Targeting the serotonin 5-HT 7 receptor in the search for treatments for CNS disorders: rationale and progress to date. CNS drugs, 29, 265-275.
Lin, H., Lee, H. G., & Yoon, M. H. (2014). Antiallodynic effects of intrathecal tianeptine in a neuropathic pain rat. Anesthesia and Pain Medicine, 9(2), 93-97.
肖智, & 文松. (2014). 中脑导水管周围灰质 5-HT7 受体在神经病理性疼痛中的镇痛作用研究. 中国疼痛医学杂志, (12), 861-865.
Ghobadifar, M. A., & Kalani, N. (2014). The potential role of intrathecal nefopam in the management of neuropathic pain. The Korean Journal of Pain, 27(3), 301-302.
Rajagopalan, R., Bandyopadhyaya, A., Rajagopalan, D. R., & Rajagopalan, P. (2014). The synthesis and comparative receptor binding affinities of novel, isomeric pyridoindolobenzazepine scaffolds. Bioorganic & Medicinal Chemistry Letters, 24(2), 576-579.
Dam, L. J., Hai, L., & Ha, Y. M. (2014). Role of the 5-HT7 receptor in the effects of intrathecal nefopam in neuropathic pain in rats. Neuroscience Letters, 566, 50-54.
Raafat, K., & Samy, W. (2014). Amelioration of diabetes and painful diabetic neuropathy by Punica granatum L. Extract and its spray dried biopolymeric dispersions. Evidence-based complementary and alternative medicine, 2014.
Radu, B. M., Iancu, A. D., Dumitrescu, D. I., Flonta, M. L., & Radu, M. (2013). TRPV1 properties in thoracic dorsal root ganglia neurons are modulated by intraperitoneal capsaicin administration in the late phase of type-1 autoimmune diabetes. Cellular and molecular neurobiology, 33, 187-196.
Quiñonez-Bastidas, G. N., Cervantes-Durán, C., Rocha-González, H. I., Murbartián, J., & Granados-Soto, V. (2013). Analysis of the mechanisms underlying the antinociceptive effect of epicatechin in diabetic rats. Life Sciences, 93(17), 637-645.
Raafat, K., Boukhary, R., Aboul-Ela, M., & El-Lakany, A. (2013). Endogenous Lebanese plants treating diabetes and related complications. Nat Prod Chem Res, 1(3), 112-20.
Ikeda, H., Ikegami, M., Kai, M., Ohsawa, M., & Kamei, J. (2013). Activation of spinal cannabinoid CB2 receptors inhibits neuropathic pain in streptozotocin-induced diabetic mice. Neuroscience, 250, 446-454.
Sałat, K., Gawlik, K., Witalis, J., Pawlica-Gosiewska, D., Filipek, B., Solnica, B., ... & Malawska, B. (2013). Evaluation of antinociceptive and antioxidant properties of 3-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-dihydrofuran-2-one in mice. Naunyn-schmiedeberg's Archives of Pharmacology, 386, 493-505.
Viguier, F., Michot, B., Hamon, M., & Bourgoin, S. (2013). Multiple roles of serotonin in pain control mechanisms—implications of 5-HT7 and other 5-HT receptor types. European journal of pharmacology, 716(1-3), 8-16.
Sakata, N., Yoshimatsu, G., Tsuchiya, H., Egawa, S., & Unno, M. (2012). Animal models of diabetes mellitus for islet transplantation. Experimental diabetes research, 2012.
Panerai, A. CONTROLLING THE ACTIVATION OF THE PROKINETICIN SYSTEM REDUCES NEUROINFLAMMATION AND ABOLISHES PAIN HYPERSENSITIVITY IN EXPERIMENTAL NEUROPATHIC PAIN.

Gunduz O, Oltulu C, Buldum D, Guven R, Ulugol A.Pharmacological characterization of the saphenous chronic constriction injury model of neuropathic pain in rats. Neurological Sciences 2011; 32(6): 1135-1142 (December 2011)

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Esmaili‐Shahzade‐Ali‐Akbari, P., Ghaderi, A., Hosseini, S. M. M., Nejat, F., Saeedi‐Mofrad, M., Karimi‐Houyeh, M., ... & Khezri, A. (2023). β_lactam antibiotics against drug addiction: A novel therapeutic option. Drug Development Research. https://doi.org/10.1002/ddr.22110 (SCI) (August 2023)
Piscura, M. K., Henderson-Redmond, A. N., Barnes, R. C., Mitra, S., Guindon, J., & Morgan, D. J. (2023). Mechanisms of cannabinoid tolerance. Biochemical Pharmacology, 115665. https://doi.org/10.1016/j.bcp.2023.115665 (SCI) (August 2023)
Ashby, D. M., LeDue, J., Murphy, T. H., & McGirr, A. (2019). Peripheral nerve ligation elicits widespread alterations in cortical sensory evoked and spontaneous activity. Scientific Reports, 9(1), 15341.
Sari, C. C., Gunduz, O., & Ulugol, A. (2019). Spinal serotonin and 5HT6 receptor levels during development of neuropathy and influence of blockade of these receptors on thermal hyperalgesia in diabetic mice. Drug Research, 69(08), 428-433.
Arribas Blázquez, M. (2017). El receptor α2 adrenérgico de la célula cromafín de la médula adrenal:¿ una nueva diana para el tratamiento del dolor neuropático?.
Ark, E. J. (2016). Cannabis therapy in patients with rheumatoid disease. The International Student Journal of Nurse Anesthesia, 15(2), 92-101.
Yang, Y., Yang, F., Yang, F., Li, C. L., Wang, Y., Li, Z., ... & Chen, J. (2016). Gabapentinoid insensitivity after repeated administration is associated with down-regulation of the α 2 δ-1 subunit in rats with central post-stroke pain hypersensitivity. Neuroscience bulletin, 32, 41-50.
Harte, S. E., Meyers, J. B., Donahue, R. R., Taylor, B. K., & Morrow, T. J. (2016). Mechanical conflict system: a novel operant method for the assessment of nociceptive behavior. PloS one, 11(2), e0150164.
Neri, L. O., de Amorim, M. M., Campos, S. A. R., Sanada, L. S., & Fazan, V. P. S. (2015). Inervación Sensorial de los Miembros Posteriores en Ratas: Comparación Morfométrica entre los Nervios Sural y Safeno. International Journal of Morphology, 33(2), 743-750.
Neri, L. O., de Amorim, M. M., Rodrigues Campos, S. A., Sanada, L. S., & Sassoli Fazan, V. P. (2015). Hind Limb Sensory Innervation in Rats: Comparison between Sural and Saphenous Nerve Morphometry. International Journal of Morphology, 33(2).
Chiang, C. Y., Sheu, M. L., Cheng, F. C., Chen, C. J., Su, H. L., Sheehan, J., & Pan, H. C. (2014). Comprehensive analysis of neurobehavior associated with histomorphological alterations in a chronic constrictive nerve injury model through use of the CatWalk XT system. Journal of neurosurgery, 120(1), 250-262.
Aydin, Ş., Yildirim, E., & Erol, K. (2013). Effects of simvastatin on experimental neuropathic pain model and the role of nitric oxide. J Analgesics, 1, 1-8.
Elmas, P., & Ulugol, A. (2013). Involvement of cannabinoid CB1 receptors in the antinociceptive effect of dipyrone. Journal of Neural Transmission, 120, 1533-1538.
Haiyan, W., Yuxiang, L., Linglu, D., Tingting, X., Yinju, H., Hongyan, L., ... & Jianqiang, Y. (2013). Antinociceptive effects of matrine on neuropathic pain induced by chronic constriction injury. Pharmaceutical Biology, 51(7), 844-850.
Kim, M. S., Seo, D. H., Lim, M. H., Kim, T. U., Lee, S. J., & Hyun, J. K. (2012). Skin temperature changes following sciatic nerve injury in rats. Journal of Neurotrauma, 29(18), 2738-2747.
Bodnar, R. J. (2012). Endogenous opiates and behavior: 2011. Peptides, 38(2), 463-522.

Gunduz O, Oltulu C, Ulugol A. Role of GLT-1 transporter activation in prevention of cannabinoid tolerance by the the beta-lactam antibiotic, ceftriaxone, in mice. Pharmacology, Biochemistry and Behaviour 2011; 99(1): 100-103 (July 2011)

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Piscura, M. K., Henderson-Redmond, A. N., Barnes, R. C., Mitra, S., Guindon, J., & Morgan, D. J. (2023). Mechanisms of cannabinoid tolerance. Biochemical Pharmacology, 115665. (sci-e) (August 2023)
Temmermand, R., Barrett, J. E., & Fontana, A. C. (2022). Glutamatergic Systems in Neuropathic Pain and Emerging Non-opioid Therapies. Pharmacological Research, 106492. (sci-e) (November 2022)
Abulseoud, O. A., Alasmari, F., Hussein, A. M., & Sari, Y. (2022). Ceftriaxone as a Novel Therapeutic Agent for Hyperglutamatergic States: Bridging the Gap Between Preclinical Results and Clinical Translation. Frontiers in Neuroscience, 16. (sci-e) (July 2022)
Saab, M., Raafat, K., & El-Maradny, H. (2022). Transdermal Delivery of Capsaicin Nanoemulgel: Optimization, Skin Permeation and In Vivo Activity against Diabetic Neuropathy. Advanced Pharmaceutical Bulletin, 12(4), 780.
ELBADAWY, M., et al. The antinociceptive and antipyretic potentials of cefepime. Adv. Anim. Vet. Sci, 2021, 9.12: 2132-2138. (July 2021)
LI, Hsin‐Hua, et al. Treatment effects of the combination of ceftriaxone and valproic acid on neuronal and behavioral functions in an epilepsy rat model. Experimental Physiology, 2021.
Furness, A. M., Pal, R., Michealis, E. K., Lunte, C. E., & Lunte, S. M. (2019). Neurochemical investigation of multiple locally induced seizures using microdialysis sampling: Epilepsy effects on glutamate release. Brain Research, 1722, 146360. (esci) (November 2019)

Gunduz O, Oltulu C, Buldum D, Guven R, Ulugol A. Anti-allodynic and anti-hyperalgesic effects of ceftriaxone in streptozocin-induced diabetic rats. Neuroscience Letters 2011; 491(1): 23-25 (March 2011)

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Wang, X., Ali, N., & Lin, C. L. G. (2021). Emerging role of glutamate in the pathophysiology and therapeutics of Gulf War illness. Life sciences, 280, 119609.
Wang X, Ali N, Lin CG. Emerging role of glutamate in the pathophysiology and therapeutics of Gulf War illness. Life Sci. 2021 Sep 1;280:119609. doi: 10.1016/j.lfs.2021.119609. Epub 2021 May 13. PMID: 33991547.
Baeza‐Flores, G. D. C., Rodríguez‐Palma, E. J., Reyes‐Pérez, V., Guzmán‐Priego, C. G., & Torres‐López, J. E. (2020). Antinociceptive effects of ceftriaxone in formalin‐induced nociception. Drug Development Research, 81(6), 728-735.
Luo, X., He, T., Wang, Y., Wang, J. L., Yan, X. B., Zhou, H. C., ... & Huang, D. (2020). Ceftriaxone relieves trigeminal neuropathic pain through suppression of spatiotemporal synaptic plasticity via restoration of glutamate transporter 1 in the medullary dorsal horn. Frontiers in Cellular Neuroscience, 14, 199.
Furgała, A., & Sałat, K. (2019, January). Antiallodynic and antihyperalgesic activity of ceftriaxone in a mouse model of neuropathic pain induced by oxaliplatin. In European Neuropsychopharmacology (Vol. 29, pp. S555-S555). PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS: ELSEVIER SCIENCE BV.
Alotaibi, G., & Rahman, S. (2019). Effects of glial glutamate transporter activator in formalin‐induced pain behaviour in mice. European Journal of Pain, 23(4), 765-783.
Bektur, E., Şahin, E., Ceyhan, E., Donmez, D. B., Canbek, M., Baycu, C., & Can, O. D. (2019). Beneficial effect of mirtazapine on diabetes-induced hyperalgesia: involvement of TRPV1 and ASIC1 channels in the spinal cord and dorsal root ganglion. Neurological Research, 41(6), 544-553.
Abdel-Daim, M. M., Aleya, L., El-Bialy, B. E., Abushouk, A. I., Alkahtani, S., Alarifi, S., ... & Bungau, S. G. (2019). The ameliorative effects of ceftriaxone and vitamin E against cisplatin-induced nephrotoxicity. Environmental science and pollution research, 26, 15248-15254.
GEGELASHVILI, Georgi; BJERRUM, Ole Jannik. Glutamate transport system as a key constituent of glutamosome: Molecular pathology and pharmacological modulation in chronic pain. Neuropharmacology, 2019, 161: 107623.
Yimer, E. M., Hishe, H. Z., & Tuem, K. B. (2019). Repurposing of the β-lactam antibiotic, ceftriaxone for neurological disorders: a review. Frontiers in Neuroscience, 13, 236.
Alshehri, F. (2018). Role of Modulating Glutamate Transporters on Hydrocodone and Alcohol Co-Abuse in Alcohol-Preferring Rats. The University of Toledo.
Kristensen, P. J., Gegelashvili, G., Munro, G., Heegaard, A. M., & Bjerrum, O. J. (2018). The β‐lactam clavulanic acid mediates glutamate transport‐sensitive pain relief in a rat model of neuropathic pain. European Journal of Pain, 22(2), 282-294.
Alshehri, F. S., Hakami, A. Y., Althobaiti, Y. S., & Sari, Y. (2018). Effects of ceftriaxone on hydrocodone seeking behavior and glial glutamate transporters in P rats. Behavioural brain research, 347, 368-376.
Wang, J., Sun, Z., Wang, Y., Wang, H., & Guo, Y. (2017). The role and mechanism of glutamic NMDA receptor in the mechanical hyperalgesia in diabetic rats. Neurological research, 39(11), 1006-1013.
Ochoa‐Aguilar, A., Sotomayor‐Sobrino, M. A., Jaimez, R., Rodríguez, R., Plancarte‐Sánchez, R., & Ventura‐Martinez, R. (2017). Antiallodynic Activity of Ceftriaxone and Clavulanic Acid in Acute Administration is Associated with Serum TNF‐α Modulation and Activation of Dopaminergic and Opioidergic Systems. Drug Development Research, 78(2), 105-115.
Gegelashvili, G., & Bjerrum, O. J. (2017). Glutamate transport system as a novel therapeutic target in chronic pain: Molecular mechanisms and pharmacology. Glial Amino Acid Transporters, 225-253.
Abdel-Daim, M. M., El-Sayed, Y. S., Eldaim, M. A., & Ibrahim, A. (2017). Nephroprotective efficacy of ceftriaxone against cisplatin-induced subchronic renal fibrosis in rats. Naunyn-Schmiedeberg's archives of pharmacology, 390, 301-309.
Li, L., Sheng, X., Zhao, S., Zou, L., Han, X., Gong, Y., ... & Liang, S. (2017). Nanoparticle-encapsulated emodin decreases diabetic neuropathic pain probably via a mechanism involving P2X3 receptor in the dorsal root ganglia. Purinergic Signalling, 13, 559-568.
PENG, Haiying, et al. lncRNA NONRATT021972 siRNA decreases diabetic neuropathic pain mediated by the P2X 3 receptor in dorsal root ganglia. Molecular Neurobiology, 2017, 54: 511-523.
Goldberg, N. S. (2016). Disrupting Disease Phenotype in Dementia with Lewy Bodies with Neural Stem Cell Transplantation. University of California, Irvine.
Shi, J., Jiang, K., & Li, Z. (2016). Involvement of spinal glutamate transporter-1 in the development of mechanical allodynia and hyperalgesia associated with type 2 diabetes. Journal of pain research, 1121-1129.
Wright, D. J., Gray, L. J., Finkelstein, D. I., Crouch, P. J., Pow, D., Pang, T. Y., ... & Hannan, A. J. (2016). N-acetylcysteine modulates glutamatergic dysfunction and depressive behavior in Huntington’s disease. Human molecular genetics, 25(14), 2923-2933.
ABDEL-DAIM, Mohamed M. Synergistic protective role of ceftriaxone and ascorbic acid against subacute diazinon-induced nephrotoxicity in rats. Cytotechnology, 2016, 68.2: 279-289.
ZHAO, Wei-Cheng, et al. Curcumin ameliorated diabetic neuropathy partially by inhibition of NADPH oxidase mediating oxidative stress in the spinal cord. Neuroscience letters, 2014, 560: 81-85.
Topuz, R. D., Gunduz, O., & Ulugol, A. (2015). 5-HT7 receptor activation: A novel target for treatment of opioid-induced hyperalgesia–A hypothesis and mini review. neurology, psychiatry and brain research, 21(3), 105-107.
Gunduz, O., Topuz, R. D., Todurga, Z. G., Duvan, K., Karadag, C. H., & Ulugol, A. (2015). Effect of activation of the GLT-1 transporter by a beta-lactam antibiotic on serotonin-induced scratching behavior in mice. Neurophysiology, 47, 36-39.
Abreu, M., Aguado, D., Benito, J., García-Fernández, J., & de Segura, I. A. G. (2015). Hyperalgesia and increased sevoflurane minimum alveolar concentration induced by opioids in the rat: a randomised experimental study. European Journal of Anaesthesiology| EJA, 32(4), 232-241.
Abreu, M., Aguado, D., Benito, J., García-Fernández, J., & de Segura, I. A. G. (2015). Tramadol-induced hyperalgesia and its prevention by ketamine in rats: A randomised experimental study. European Journal of Anaesthesiology| EJA, 32(10), 735-741.
Abdel-Daim, M. M., & El-Ghoneimy, A. (2015). Synergistic protective effects of ceftriaxone and ascorbic acid against subacute deltamethrin-induced nephrotoxicity in rats. Renal failure, 37(2), 297-304.
Pandey, A. K. (2014). New Approach to Chronic Pain Therapy with Drugs Targeting Glutamate Transporter. International Journal of Pharmaceutics and Drug Analysis, 2(2), 70-73.
Too, L. K., Ball, H. J., McGregor, I. S., & Hunt, N. H. (2014). A novel automated test battery reveals enduring behavioural alterations and cognitive impairments in survivors of murine pneumococcal meningitis. Brain, behavior, and immunity, 35, 107-124.
Gegelashvili, G., & Bjerrum, O. J. (2014). High‐affinity glutamate transporters in chronic pain: an emerging therapeutic target. Journal of neurochemistry, 131(6), 712-730.
Stepanovic-Petrovic, R. M., Micov, A. M., Tomic, M. A., Kovacevic, J. M., & Boškovic´, B. D. (2014). Antihyperalgesic/antinociceptive effects of ceftriaxone and its synergistic interactions with different analgesics in inflammatory pain in rodents. Anesthesiology, 120(3), 737-750.
WANG, Shouyu, et al. LncRNA uc. 48+ is involved in diabetic neuropathic pain mediated by the P2X 3 receptor in the dorsal root ganglia. Purinergic signalling, 2016, 12: 139-148.
Ulugol, A. (2013). Reduction of dependence to cannabinoids by GLT-1 activating property of the beta-lactam antibiotic. Medical hypotheses, 80(3), 247-248.
Karaman, I., Kizilay-Ozfidan, G., Karadag, C. H., & Ulugol, A. (2013). Lack of effect of ceftriaxone, a GLT-1 transporter activator, on spatial memory in mice. Pharmacology Biochemistry and Behavior, 108, 61-65.
Nones, C. F. M., Reis, R. C., Jesus, C. H. A., da Luz Veronez, D. A., Cunha, J. M., & Chichorro, J. G. (2013). Orofacial sensory changes after streptozotocin-induced diabetes in rats. Brain research, 1501, 56-67.
Ulugol, A., Oltulu, C., Gunduz, O., Citak, C., Carrara, R., Shaqaqi, M. R., ... & Dogrul, A. (2012). 5-HT7 receptor activation attenuates thermal hyperalgesia in streptozocin-induced diabetic mice. Pharmacology Biochemistry and Behavior, 102(2), 344-348.
Stephens Jr, R. L. (2011). Glutamate transporter activators as anti-nociceptive agents. The Eurasian journal of medicine, 43(3), 182.
Schroeder, J. A., Quick, K. F., Landry, P. M., & Rawls, S. M. (2011). Glutamate transporter (GLT-1) activation enhances nicotine antinociception and attenuates nicotine analgesic tolerance. Neuroreport, 22(18), 970.
Hobo, S., Eisenach, J. C., & Hayashida, K. I. (2011). Up-regulation of spinal glutamate transporters contributes to anti-hypersensitive effects of valproate in rats after peripheral nerve injury. Neuroscience letters, 502(1), 52-55.

International Articles

Oltulu, Ç. & Daşman, M. (2024). DETERMINATION OF TOXIC METALS IN SOME FOOD SUPPLEMENTS BY ICP-MS . Journal of Faculty of Pharmacy of Ankara University , 48 (1) , 8-8 . DOI: 10.33483/jfpau.1279257 (in press) (November 2023)

Oltulu, Ç. , Akıncı, M. & Bakar, E. (2023). Evaluation of the effect of topotecan, carvacrol, epigallocatechin gallate and their combination on apoptotic process in neuroblastoma and astrocyte cells . Fabad Journal of Pharmaceutical Sciences , 48 (3) , 373-384 . DOI: 10.55262/fabadeczacilik.1301973 (October 2023)

AKINCI M, OLTULU Ç, BAKAR E, ÇEVİKELLİ YAKUT ZA. Galangin Protects AML-12 Cells Against Dactinomycin Induced Hepatotoxicity. Namik Kemal Med J 2023;11:257-264. doi: 10.4274/nkmj.galenos.2023.09226 (September 2023)

AKINCI M, OLTULU Ç, BAKAR E, ÇEVİKELLİ YAKUT ZA. Puerarin Protects from Methotrexate Induced Hepatotoxicity in AML-12 Cells. Namik Kemal Med J 2023;11:193-201. https://doi.org/10.4274/nkmj.galenos.2023.27147 (September 2023)

Oltulu, Ç., Çelik, S., & Daşman, M. (2023). Determination of sildenafil and tadalafil adulteration by LC-MS/MS and 23 elements by ICP-MS in food supplements. İstanbul Journal of Pharmacy, 53(2), 219-228. https://doi.org/10.26650/IstanbulJPharm.2023.1206425 (August 2023)

Oltulu, C. & Turker, N.P. (2023). Effect of L-Dopa on Carboplatin Induced Hepatotoxicity . International Journal of Innovative Approaches in Science Research, 7(1), 37-46. https://doi.org/10.29329/ijiasr.2023.524.4 (March 2023)

Çağatay OLTULU, Melek AKINCI, Elvan BAKAR Antitumor Activity of Etoposide, Puerarin, Galangin and Their Combinations in Neuroblastoma Cells.Int J. Life Sci. Biotechnol. (15.12.2022) https://doi.org/10.38001/ijlsb.1089164 (December 2022)

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ATIF

.SEZER YAVUZ ATAKAN,SAGIROGLU TAMER,ÇOPUROGLU ELIF,YAGCI MEHMET ALI,OLTULU ÇAGATAY,SÜT NECDET, A New Tube Gastrostomy Model in Animal Experiments, Journal of Clinical and Analytical Medicine, vol. 4, no. 1, pp. 5-8, 2013.

International Conference Proceedings

Arjeta Simitciu, Çağatay Oltulu, Ahmet Doğan Ergin. In-Vitro Evaluation of The Cytotoxic Effect Of Cerium Oxide Particles With Different Particle Sizes On Human Aortic Vascular Smooth Muscle. V. International Agricultural, Biological & Life Science Conference, Edirne, Turkey, 18-20 September 2023 Edirne Turkey. (Oral Presentation) (Eylül 2023) (September 2023)

Çağatay Oltulu. CYTOTOXIC POTENTIAL OF CERIUM ION. V. International Agricultural, Biological & Life Science Conference, Edirne, Turkey, 18-20 September 2023 Edirne Turkey. (Oral Presentation) (September 2023)

Afşar O, OLTULU C. CYTOTOXIC EFFECT OF BROOKITE TITANIUM DIOXIDE NANOPARTICLES. INTERNATIONAL KHAZAR SCIENTIFIC RESEARCHES CONFERENCE - IV March 1-2, 2023 / Khazar University - Baku, Azerbaijan (March 2023)

Cagatay Oltulu, Melek Akinci, Elvan Bakar. Effect of melphalan and epigallocatechin gallate combinations on cytotoxicity in neuroblastoma cell line. 11th International Congress of the Turkish Society of Toxicology (TST), Antalya. (02-05.11.2022) (November 2022)

Çağatay Oltulu, Nebiye Pelin Türker. EFFECT OF L-DOPA ON LIVER CYTOTOXICITY. IV. International Agricultural, Biological & Life Science Conference, Edirne, Turkey, 29-31 August 2022 Edirne Turkey. (Oral Presentation) (August 2022)

Çağatay Oltulu, Melek Akıncı, Elvan Bakar. Evaluation of the cytotoxic effect of the combination of carboplatin and carvacrol. 3rd international cancer and ion channels congress 16-18 september 2021 (September 2021)

Oltulu, C., Bakar, E., Akinci, M. THE EFFECTS OF CARVACROL AND EPIGALLOCATECHIN GALLATE ON DRUG RESISTANCE IN NEUROBLASTOMA CELL LINE. 13th International Symposium on Pharmaceutical Sciences (ISOPS) 22-25 June 2021. book of abstracts ISBN 978-605-136-537-4 (June 2021)

Ahmet Doğan Ergin, Büşra Koç, Çağatay Oltulu, ''Preparation, Characterization And In-Vitro Evaluation Of Sustained Release 6-Mercaptopurine Loaded Solid Lipid Nanoparticles'' II. International Agricultural, Biological & Life Science Conference September 1-3, 2020 Edirne, Turkey (September 2020)

ERGIN AHMET DOGAN, KOÇ BÜSRA, OLTULU ÇAGATAY, PREPARATION, CHARACTERIZATION AND IN-VITRO EVALUATION OF SUSTAINED RELEASE 6-MERCAPTOPURINE-LOADED SOLID LIPID NANOPARTICLES, II. International Agricultural, Biological & Life Science Conference, Edirne, Turkey, 1-3 September, 2020, Edirne-TÜRKIYE.

Akinci M, Oltulu C, Karadag CH, Chousein S, Gündüz Ö, Topuz RH. The Effects of In-vitro Used Amitriptyline, Fluoxetine, Tranylcpromine and Venlafaxine on Saphenous Vein Grafts That are Oftenly Used in Coronary Artery Bypass Surgery. Association of Thrace Universities 1st International Health Sciences Congress 2017 (November 2017)

Oltulu C, Akinci M, Tugce Yesil, Akgul V, Akgun S, Motor D, Canbaz S, Sardas S. Investigation of genotoxicity risk in healthcare workers that has occupational exposure to antineoplastic drugs. EUROTOX 2017 53rd congress of the European Societies of Toxicology Toxicology Letters Volume 280, Supplement 1, 20 October 2017, Page S119 https://doi.org/10.1016/j.toxlet.2017.07.334 (September 2017)

ULUGOL A, OLTULU Ç, GUNDUZ O, CITAK C, CARRARA R, SHAQAI MR, SANCHEZ AM, DOĞRUL A. Effects of 5-HT7 receptor activation on changes in thermal sensitivity in streptozocin-induced diabetic mice. 13th World Congress of Pain 2012. Milan, ITALY, 27-31 August 2012 (August 2012)

GUNDUZ O., OLTULU C., BULDUM D., GUVEN R., ULUGOL A. Anti-allodynic and anti-hyperalgesic effects of ceftriaxone in streptozocin-induced diabetic rats. Pain in Europe VII, 7th Congress of European Federation of IASP Chapters. Hamburg, GERMANY, 21-24 September 2011 (September 2011)

GUNDUZ O., OLTULU C., ULUGOL A. Role of GLT-1 transporter activation in prevention of cannabinoid tolerance by the beta-lactam antibiotic, ceftriaxone, in mice. 8th IBRO World Congress of Neuroscience. Florence, ITALY, 14-18 July 2011 (July 2011)

GUNDUZ O., OLTULU C., GUVEN R., BULDUM D., ULUGOL A. Pharmacological and behavioral characterization of the saphenous chronic constriction injury model of neuropathic pain in rats. 22th International Medical Sciences Student Congress. Istanbul, TURKEY, 14-16 May 2010 (May 2010)

International Conferences and Symposiums

Third East Mediterranean ICLAS Symposium and XV. ICLAS General Assembly, Istanbul Turkey (June 2011)

International Books and Book Chapters

Oltulu C. & Dasman (2023) Oxidative Stress Induced Toxicity. In Isik, M. & Duran M.S. (Eds.), Recent Advances in Molecular Biology and Biochemistry (pp. 284-297). Istanbul, Turkey: Biyomit Publisher. ISBN: 978-605-71699-4-5 (August 2023)

National Articles

Cagatay Oltulu, Tugce Yesil Devecioglu, Melek Akinci, Sevcan Gul Akgun Olmez, Serra Vildan Obeidin, Ayfer Beceren. Evaluation of Genotoxicity Risk in Health Care Workers Exposed to Antineoplastic Drugs. Clin Exp Health Sci 2019;9(2); 166-170 (esci) (June 2019)

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ATIF

ATIFLAR

Vanneste, D., Verscheure, E., Srinivasan, A. N., Godderis, L., & Ghosh, M. (2023). Systematic review of genotoxicity induced by occupational exposure to antineoplastic drugs. Archives of Toxicology, 1-65. (June 2023)
Rivero, S. E., & Gonzalez-Argote, J. (2022). Percepciones sobre la gestión, exposición, bioseguridad y manipulación de citostáticos en el personal de enfermería de una institución de salud privada de la Ciudad Autónoma de Buenos Aires. Medicina y Seguridad del Trabajo, 68(267), 118-129. (esci) (December 2022)
MRDJANOVIĆ, Jasminka, et al. The Oxidative Stress Parameters as Useful Tools in Evaluating the DNA Damage and Changes in the Complete Blood Count in Hospital Workers Exposed to Low Doses of Antineoplastic Drugs and Ionizing Radiation. International Journal of Environmental Research and Public Health, 2021, 18.16: 8445. (sci-e) (August 2021)
ZHU, Bingke, et al. Mapping the scientific research on healthcare workers’ occupational health: A bibliometric and social network analysis. International journal of environmental research and public health, 2020, 17.8: 2625. (sci-e) (April 2020)
FARROÑÁN-SONDOR, Roberto Edgar; SERQUÉN-LÓPEZ, Luis Miguel. Ensayo cometa: una prueba necesaria para la detección de genotoxicidad en profesionales de la salud. Revista Experiencia en Medicina del Hospital Regional Lambayeque, 2019, 5.3: 146-147. (October 2019)
Farroñán-Sondor, R. E., & Serquén-López, L. M. (2019). Ensayo cometa: una prueba necesaria para la detección de genotoxicidad en profesionales de la salud. Revista Experiencia en Medicina del Hospital Regional Lambayeque, 5(3), 146-147. (thesis)

Sezer A, Sağıroğlu T, Çopuroğlu E, Yağcı M, Oltulu Ç, Süt N. A New Tube Gastrostomy Model. Journal of Clinical and Analytical Medicine 2013;4(1):5-8. (January 2013)

3
ATIF

National Conference Proceedings

GEDIK GÜLSAH, SARP ÖNDER, NAZLI HAKAN, OLTULU ÇAGATAY, GÜNDÜZ ÖZGÜR, New approaches in creating neuropathic pain model with oxaliplatin in mice, I. National Marmara Pharmacy Congress, Istanbul-TURKEY

Melda Canbaz, Manuk Norayk Manukyan, Uğur Deveci, Çağatay Oltulu, Abut Kebudi, Ahmet Midi, Aynur Eren Topkaya. In rats with experimental gastroesophageal reflux; Demonstrating the Effect of Nutrition Enriched with Whey Proteins on the Development of Reflux Esophagitis.19. National Surgery Congress, Antalya, 20 April 2014 (April 2014)

Oltulu C, Montenegro CH. : The effect of intrauterine exposure to antipsychotic drugs on learning and memory in adult rats. 22nd National Pharmacology Congress. Antalya, 4-7 November 2013. (November 2013)

ULUGOL A., OLTULU C., GÜNDÜZ Ö., ÇITAK C., CARRARA R., SHAQAQI MR., SANCHEZ AM., DOĞRUL A. Effect of 5-HT7 receptor activation on thermal sensitivity changes in streptozocin-induced diabetic mice. 12th National Pain Congress. Istanbul, 17-20 May 2012 (May 2012)

GÜNDÜZ Ö., OLTULU C., BULDUM D., GÜVEN R., ULUGÖL A. Anti-allodynic and anti-hyperalgesic effects of ceftriaxone in rats induced diabetes by streptozocin. 21st National Pharmacology Congress. Eskişehir, 19-22 October 2011 (Oral presentation) (October 2011) (October 2011)

GÜNDÜZ Ö., OLTULU C., ULUGÖL A. The role of GLT-1 transporter activation in the efficacy of ceftriaxone on the development of tolerance to cannabinoid effects in mice. 21st National Pharmacology Congress. Eskisehir, 19-22 October 2011 (October 2011)

GÜNDÜZ Ö., OLTULU C., GÜVEN R., BULDUM D., ULUGÖL A. Pharmacological and behavioral characterization of chronic constriction injury of the saphenous nerve as a rat neuropathic pain model. 36th National Physiology Congress. Edirne, 14-17 September 2010. (September 2010) (September 2010)

National Conferences and Symposiums

Ethics Symposium in Animal Experiments in Türkiye
Ethical Principles in Scientific Research and Publications Symposium

Memberships

Turkish Pharmacological Society
Turkish Society of Toxicology

Projects

Effects of Sitagliptin and L-Theanine Combined Treatment on Testicular Tissue in Experimental Diabetes Rats, TUBAP 2022/202

Investigation of the Efficacy of Curcumin on the Hepatotoxic and Nephrotoxic Effects of Favipiravir in Rats, TUBAP 2022/169

In-vitro evaluation of the cytotoxic effect of cerium oxide particles with different particle sizes on human aortic smooth muscle, 2022

Preparation of 6-mercaptopurine loaded solid lipid nanoparticle formulations and investigation of cytotoxic and anticancer effect in hepatocellular carcinoma cell line, 2021.

Investigation of the effect of titanium dioxide nanoparticles on DNA damage in human embryonic lung cells TÜBAP 2021/29

Investigation of the Effect of Intestinal Microbiota Supplemented with Lactobacillus acidophilus on the Expression of miRNAs in a Rat Colon Cancer Model. TUBİTAK 1001

Investigation of hepatoprotective activities of different antioxidants on the toxic effects of antineoplastic agents in human hepatocyte cell culture. TUBAP 2018/274

In-vitro evaluation of the chemoprotective activities of some antioxidants on the cytotoxic effect of antineoplastic agents used in the treatment of neuroblastoma.

The Effects of In vitro Amitriptyline Fluoxetine Tranylcypromine and Venlafaxine on Internal Thoracic Artery and Saphenous Vein Grafts Frequently Used in Coronary Artery Bypass Surgery TUBAP 2013/34

Awards

3th place, Best Diabetes Mellitus article award. Gunduz O, Oltulu C, BUldum D, Guven R, Ulugol A. Anti-allodynic and anti-hyperalgesic effects of ceftriaxone in streptozocin-induced diabetic rats. Neuroscience Letters 2011; 491(1): 23-25

1st place, poster presentation award. 22nd International Medical Sciences Student Congress, Istanbul. Gunduz O, Oltulu C, BUldum D, Guven R, Ulugol A.Pharmacological characterization of the saphenous chronic constriction injury model of neuropathic pain in rats. Neurological Sciences 2011; 32(6): 1135-1142 (May 2010)

Certificates

First Aid Training (T.C. Edirne Valiliği İl Sağlık Müdürlüğü,2022)
Adult Basic Education Skills (May 2015)
TÜFTAD Advanced Technology Products and Repayments training meeting (May 2015)
Artificial Insemination Course with Recto-Vaginal Method in Cattle
Food Safety and HACCP Practices Training, Istanbul
ISO 9001:2000 Internal Quality Inspector, Istanbul

» Educational Qualifications

High School » Graduated in 1997

Bachelor`s Degree » Graduated in 2006

Doctoral Degree » Graduated in 2013

Doctoral Degree Thesis;

» Academic Titles

Assistant Professor » In 2013

» Publications

SCI-SSCI or SCI Expanded Articles

International Articles

International Conference Proceedings

International Conferences and Symposiums

International Books and Book Chapters

National Articles

National Conference Proceedings

National Conferences and Symposiums

Memberships

Projects

Awards

Certificates